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Figure 3 | BMC Cancer

Figure 3

From: Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo

Figure 3

Treatment with an inhibitory antibody against the IGF-IR. One million U87 cells were injected subcutaneously into the rear flanks of athymic nude mice. Mice received intraperitoneal injections of 100 μg of αIR3 or control IgG every two days starting on the third day after inoculation with cells. Each group consisted of eight mice that each received two injections of cells. Tumors were excised, fixed, sectioned and stained for apoptosis using the TUNEL assay. Left panel shows tumor from mice treated with control IgG; right panel shows tumor from mice treated with αIR3. TUNEL positive cells show green fluorescence.

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