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Scheme 1 | BMC Cancer

Scheme 1

From: Radioactive 125I seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway

Scheme 1

Proposed signaling pathway by which radioactive 125I seeds inhibit epithelial–mesenchymal transition (EMT) and cell growth in glioblastoma multiforme (GBM) cells

Proposed signaling pathway by which radioactive125I seeds inhibit epithelial–mesenchymal transition (EMT) and cell growth in glioblastoma multiforme (GBM) cells.125I seeds act indirectly through radiolysis of water, thereby generating ROS and producing DNA damage. DNA damage activates the sensory ATM/ATR kinases and finally results in cell growth inhibition and G2/M arrest. Moreover, ROS induced by 125I seeds can inhibit EMT via Cav-1 in GBM cells.

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