Table 2 Enriched gene networks upregulated via FoxO during cancer cachexia

x

x

x

x

proteasome subunit, alpha type, 7

Psma7

2.40

1.38

x

x

x

x

proteasome subunit, alpha type, 2

Psma2

2.95

1.73

x

x

x

x

proteasome 26S subunit, ATPase, 2

Psmc2

2.31

1.47

x

x

x

x

proteasome 26S subunit, ATPase, 4

Psmc4

2.47

1.49

x

x

x

x

proteasome 26S subunit, non-ATPase, 3

Psmd3

2.15

1.34

x

x

x

x

proteasome 26S subunit, non-ATPase, 4

Psmd4

2.67

1.69

x

BCL2-like 11 (apoptosis facilitator)

Bcl2l11

3.01

1.82

x

x

FBJ murine osteosarcoma oncogene

Fos

16.75

5.70

x

x

jun B proto-oncogene

Junb

5.40

2.48

x

early growth response 1

Egr1

4.07

1.95

x

matrix metallopeptidase 9

Mmp9

2.52

1.57

x

FOS-like antigen 2

Fosl2

3.50

2.09

x

angiotensinogen

Agt

5.00

2.64

x

FBJ murine osteosarcoma oncogene B

Fosb

3.90

1.43

x

x

f-box and WD-40 domain protein 11

Fbxw11

1.88

1.15

x

x

murine thymoma viral oncogene homolog 1

Akt1

2.61

1.54

x

x

BCL2-like 1

Bcl2l1

3.01

1.82

x

x

suppressor of cytokine signaling 3

Socs3

6.63

3.08

x

CCAAT/enhancer binding protein beta

Cebpb

2.94

1.82

x

kelch-like ECH-associated protein 1

Keap1

1.95

1.25

x

splA/ryanodine receptor dom and SOCS box

Spsb1

6.36

3.91

Other genes of interest

immediate early response 5

Ier5

3.46

1.74

immediate early response 3

Ier3

3.02

1.64

ubiquilin-1

Ubqln1

1.93

1.25

f-box protein 31

Fbxo31

3.25

1.79

BCL2/adenovirus E1B interacting protein 3

Bnip3

2.53

1.51

Cathepsin L

Ctsl

3.07

1.79

GABA(A) receptor-associated protein like 1

Gabarapl1

4.44

2.52

Heme Oxygenase 1

Hmox1

5.91

1.68