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Figure 2 | BMC Cancer

Figure 2

From: Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia

Figure 2

Inhibition of FoxO impedes C26-induced muscle fiber atrophy and weakness. (A-D) The average cross-sectional area of muscle fibers in the TA (A), EDL (B) and diaphragm (C) of control or cachectic C26 mice transduced with AAV9-ev or AAV9-d.n.FoxO was calculated following incubation of muscle cross-sections with Alexa Fluor-conjugated wheat germ agglutinin to label muscle fiber membranes. (D) Representative diaphragm muscle cross-sections from each group. Data represent mean ± SE, n = at least 6 animals per group. (E-H) Maximum absolute tetanic force (E), specific force (F), time to peak tension (G) and half-relaxation time (H) was calculated in EDL muscles from control or cachectic C26 mice transduced with AAV9-ev or AAV9-d.n.FoxO. Data represent mean ± SE, n = 4 animals/group. *p < 0.05 vs AAV9-ev control group. †p < 0.05 vs. AAV9-ev C26 group.

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BMC Cancer

ISSN: 1471-2407

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