Figure 3

SIRT1 promotes hepatocellular carcinoma (HCC) tumorigenicity in vivo . (A) and (C) Photographs of metastatic liver nodules in nude mice by splenic-vein injection of SMMC-7721 cells untreated or treated with nicotinamide (50 μM), resveratrol (25 mg/mL), Ad-SIRT1, Ad-control, sh-SIRT1, or sh-control. (B) and (D) The rate of occurrence of metastatic nodules was quantified in nude mouse livers (n = 8 per group). Values for individual mice are shown above the bars (*P < 0.05).