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Figure 3 | BMC Cancer

Figure 3

From: Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer

Figure 3

Pathway analyses of gene expression changes in response to docetaxel chemotherapy with ADT. (A) Log2 fold change of genes enriched (enrichment > 2-fold; FDR < 0.05) within the KEGG (Kyoto Encyclopedia of Genes and Genomes) [26] term “Cell Cycle” following docetaxel plus ADT treatment. (B) Matrix heatmap generated using cBioPortal [28, 29] showing alterations in expression of 5 genes from within the KEGG term “Cell Cycle” (BUB1B, CCNB1, CCNB2, TTK, and CDK1) in the MSKCC Prostate Oncogenome Project dataset [30]. (C) Kaplan Meier plot showing the survival curves of patients in the MSKCC Prostate Oncogenome Project dataset with and without alterations in expression of the 5 cell cycle-related genes (p = 0.024). (D) Kaplan Meier plot showing the survival curves of patients in the MSKCC Prostate Oncogenome Project dataset with and without alterations in expression of the genes in the candidate biomarker panel (ADAM7, FAM72B, BUB1B, CCNB1, CCNB2, TTK and CDK1) (p = 0.015).

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BMC Cancer

ISSN: 1471-2407

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