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Figure 2 | BMC Cancer

Figure 2

From: Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer

Figure 2

Differential expression of genes affected by docetaxel chemotherapy plus ADT. (A) Log2 fold change of 6 of the 10 top-ranking differentially-expressed genes (Log2 fold change ≥ 2/≤ - 2; FDR < 0.05) consistent in the direction of expression changes in at least 3 out of 4 individual patients. (B) Matrix heatmap generated using cBioPortal [28, 29] showing alterations in expression of 6 of the top 10 differentially-regulated genes (exhibiting consistent expression changes in at least 3 out of 4 patients in the present study) in the MSKCC Prostate Oncogenome Project dataset [30]. (C) Kaplan Meier plot showing the survival curves of patients in the MSKCC Prostate Oncogenome Project dataset with and without alterations in expression of FAM72B and ADAM7 (p = 0.001).

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BMC Cancer

ISSN: 1471-2407

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