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Figure 1 | BMC Cancer

Figure 1

From: Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer

Figure 1

Differential expression of androgen-regulated genes in response to docetaxel chemotherapy plus ADT. (A) Circos plot [25] of the transcriptomic landscape of docetaxel chemotherapy plus ADT in PCa. The outer ring shows chromosome ideograms with labelled chromosome identities. The scatter plot shows up- (Red) and down- (Blue) regulated genes. Gene fusions are shown as coloured arcs linking two genomic loci. (B) Log-log plot demonstrating correlation between KLK3 (encodes PSA) mRNA expression levels (X-axis) normalized by trimmed means of M-value (TMM) in normalized counts per million (ncpm) and serum PSA levels (ng/ml) (Y-axis) (r2 = 0.927; p = 0.037). (C) Expression of known androgen-regulated genes (Log2 fold change ≥ 2; FDR < 0.05) following docetaxel plus ADT.

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BMC Cancer

ISSN: 1471-2407

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