Table 3 Detailed results of subgroup analyses for prognostic and predictive significance

Response rate(RRⁱ) ¶ⁱⁱ

1.740[0.878-3.447], I ² = 75.4%

1.258[0.990-1.598], I ² = 6.9%;Fixed:1.263 [1.008-1.584],I ² = 6.9%

2.315[1.242-4.316], I ² = 0%

1.326[0.904-1.946],I ² = 22.5%

5.2174 [2.3258-11.7041], N = 1ⁱⁱⁱ

1.258[0.990-1.598], I ² = 6.9%;Fixed:1.263 [1.008-1.584],I ² = 6.9%

2.315[1.242-4.316],I ² = 0%

Disease control rate(RR) Ψ^iv

1.354[1.002-1.830], I ² = 80.8%

1.375[0.961-1.967], I ² = 77.4%

1.535[1.170-2.016],I ² = 69.8%

1.110[0.784-1.571],I ² = 74.6%

2.005[1.052-3.821], I ² = 87.7%

0.974[0.933-1.016], I ² = 0.0%

1.451[1.116-1.887],I ² = 36.3%

Disease control rate(RR) ¶

1.354[1.065-1.721], I² = 59.5%

1.248[0.874-1.783], I ² = 74.7%

1.331[1.099-1.612], I ² = 35.9%

1.292[1.005-1.660], I ² = 42.4%

1.933[0.633-5.902],I ² = 86.0%

0.974[0.933-1.016], I ² = 0.0%

1.451[1.116-1.887],I ² = 36.3%

CTCs change

Disease control rate (OR^v: increase VS decrease) Ψ

27.088[4.960- 147.919], I ² = 0.0%

/

/

39.000[2.932- 518.841], N = 1

20.570[2.170-194.950], N = 1

/

/

HR^vi for PFS^vii(L/H to H VS H to L^viii) ¶

2.095[1.105-3.969], I ² = 74%

/

/

2.095[1.105-3.969], I ² = 74%

/

/

/

HR for OS(L/H to H VS H to L) ¶

3.604[2.096-6.197], I ² = 52.9%

/

/

3.604[2.096-6.197], I ² = 52.9%

/

/

/

Prognosis

HR for PFS Ψ

2.500[1.746-3.580], I ² = 90.0%; Without Matsusaka 2.654[2.069-3.405], I ² = 58.1%

1.853[1.405-2.445], I ² = 83.6%; Without Matsusaka 1.942[1.549-2.435], I ² = 47.6%

2.386[1.454-3.917],I ² = 93.3%; Without Matsusaka 2.694[2.085-3.481], I ² = 35.1%

1.769[1.180-2.651],I ² = 90.2%; Without Matsusaka 2.059[1.563-2.712], I ² = 50.4%

3.387[2.479-4.628],I ² = 32.7%

1.422[1.102-1.835], I ² = 82.5%; Without Matsusaka 1.578[1.355-1.837], I ² = 0%

2.127[1.190-3.802], I ² = 95%;

Without Matsusaka 2.697[2.208-3.294], I ² = 0%

HR for PFS

2.237[1.485-3.370], I ² = 91.8%; Without Matsusaka 2.476[1.830-3.350], I ² = 68.0%

1.621[1.224-2.146], I ² = 83.6% Without Matsusaka 1.736[1.383-2.180], I ² = 44.5%

2.100[1.273-3.465],I ² = 93.7%; Without Matsusaka 2.593[2.152-3.124], I ² = 0.0%

1.769[1.180-2.651],I ² = 90.2%; Without Matsusaka 2.059[1.563-2.712], I ² = 50.4%

3.618[1.976-6.624],I ² = 65.8%

1.422[1.102-1.835], I ² = 82.5%; Without Matsusaka 1.578[1.355-1.837], I ² = 0%

2.127[1.190-3.802], I ² = 95%;

Without Matsusaka 2.697[2.208-3.294], I ² = 0%

Operation: HR for PFS¶

3.433[2.111-5.583],I ² = 72.8%

2.377[1.692-3.339], I ² = 18.8%

3.344[1.135-9.852], I ² = 75.6%

1.981[1.478-2.654], N = 1

4.265[3.079-5.907],I ² = 0.0%

1.943[1.362-2.770], N = 1

2.063[1.231-3.458], N = 1

HR for OS^ix¶

2.856[1.959-4.164],I ² = 83.4%; Without Matsusaka 3.139[2.167-4.545],I ² = 76.1%

2.356[1.957-2.836], I ² = 14.0%; Without Matsusaka 2.288[1.941-2.697], I ² = 1.7%

3.292[1.611-6.726],I ² = 96.2%; Without Matsusaka 3.998[2.478-6.449], I ² = 79.5%

2.452[1.484-4.050],I ² = 89.9%; Without Matsusaka 2.895[1.697-4.940], I ² = 85.9%

3.367[1.882-6.023],I ² = 68.6%

2.310[1.759-3.035], I ² = 49.9%; Without Matsusaka 2.210[1.716-2.846], I ² = 46.8%

2.802[1.175-6.684],I ² = 97.4%; Without Matsusaka 3.792[2.052-7.009],I ² = 86.5%

HR for OS¶

2.642[1.716-4.067],I ² = 86.2%; Without Matsusaka 2.968[1.913-4.606],I ² = 80.4%

2.373[1.873-3.006], I ² = 34.3%; Without Matsusaka 2.284[1.836-2.842], I ² = 27.6%

2.787[1.321-5.882],I ² = 96.6%; Without Matsusaka 3.536[2.149-5.818],I ² = 81.8%

2.452[1.484-4.050], I ² = 89.9%; Without Matsusaka 2.895[1.697-4.940],I ² = 85.9%

2.969[1.053-8.375],I ² = 78.2%

2.310[1.759-3.035], I ² = 49.9%; Without Matsusaka 2.210[1.716-2.846], I ² = 46.8%

2.802[1.175-6.684],I ² = 97.4%; Without Matsusaka 3.792[2.052-7.009],I ² = 86.5%

Operation: HR for OS¶

3.681[1.833-7.394],I ² = 81.8%

1.890[1.407-2.539], I ² = 0.0%

4.069[0.872-18.980],I ² = 87.0%

1.738[1.296-2.332], N = 1

4.678[2.267-9.654],I ² = 67.5%

1.642[1.149-2.345], N = 1

1.961[1.168-3.295], N = 1