Reference | Number (M/F) | C/R/RS | ST | CRT before and after ST | Age mean ± SD/ median (range) | Methods | Rate(+) | Follow up mean ± SD/median (range) | Tumor stage | HR (method no.) | OM | Surgery |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Barbazan 2014 [30] | 50(37/13) | 34/14 | baseline | NO/YES | 64.5 ± 10.3; 31-84 | RT-PCR | 13/50 | 0-40 | mCRC | PFS,OS(3) | PFS,OS, | NR |
 |  |  | 4 W; 16 W | YES/YES | 64.5 ± 10.3; 31-84 | RT-PCR | 12/50; 15/50 | 0-40 | mCRC | PFS,OS(3); PFS,OS(11) | PFS,OS, RECIST | NR |
Kuboki 2013 [34] | 63(34/29) | 41/22/0 | baseline | NO/YES | 61(33–81) | Cellsearch | 19/63 | median:8.7 | mCRC | PFS,OS(3) | PFS,OS, RECIST | NR |
Lu 2013 [36] | 90(51/39) | 90/0/0 | 1,4 W | YES/YES | 63.1 ± 12.9 | membrane-array | 21/90 | 36(18–61) | III stage | PFS,OS(3) | PFS,OS | YES |
Iinuma(1) 2013 [35] | Training: 420(224/196) | NR | baseline | NO/YES | 66.0 ± 12.4 | RT-PCR | 57/150 | 36.9 ± 19.5 | Dukes’ C | PFS,OS(3) | PFS,OS | YES |
Iinuma(2) 2013 [35] | Validation: 315(175/140) | NR | baseline | NO/YES | 67.5 ± 11.8 | RT-PCR | 35/97 | 37.1 ± 18.1 | Dukes’ C | PFS,OS(3) | PFS,OS | YES |
Sastre 2012 [26] | 180(118/62) | 121/40/19 | baseline | NO/YES | 65(40–82) | Cellsearch | 85/180 | 29(0–53.2) | mCRC | PFS,OS(3) | PFS,OS, RECIST | 123YES |
 | 147 | NR | cycle3 | YES/YES | NR | Cellsearch | 23/147 | NR | mCRC | PFS,OS(3) | PFS,OS, RECIST | 123YES |
de Albuquerque 2012 [27] | 60(43/17) | NR | baseline | NO/YES | 65.2(40–80) | RT-PCR | 23/33 | 8.1(6.4-9.7) | II-IV stage | PFS(10) | PFS, RECIST | NR |
 | 33 | NR | 1-4 W; 5-8 W; 9-12 W | YES/YES | NR | RT-PCR | 18/33; 19/33; 17/33 | NR | NR | NR | RECIST | NR |
Matsusaka 2011 [28] | 64(31/33) | 36/28 | baseline | NO/YES | 59(18–72) | Cellsearch | 12/64 | 0-36 | mCRC | PFS(3);OS(10) | PFS,OS, RECIST | NR |
 | / | NR | 2 W; 8-12 W | YES/YES | NR | Cellsearch | 7/63; 4/60 | NR | mCRC | PFS(3);OS(10) | PFS,OS, RECIST | NR |
Konigsberg 2010 [33] | 38(23/15) | NR | mixed | NO/YES | 65(44–82) | ICC | 23/38 | 11.7(8.4-14.9) | mCRC | PFS,OS(3) | PFS,OS, RECIST | NR |
Yalcin 2010 [32] | 93(50/43) | NR | mixed | part NO/YES | 56(24–78) | Cellsearch | 30/93 | 6 | II-IV stage | NR | RECIST | PART YES |
Tol 2010 [29] | 467(284/183) | 225/122/120 | baseline | NO/YES | 63(27–83) | Cellsearch | 129/451 | 16.8 | mCRC | PFS,OS(3) | PFS,OS, RECIST | NO |
 | / | NR | 1-2 W | YES/YES | NR | Cellsearch | 21/368 | NR | mCRC | PFS,OS(3) | PFS,OS, RECIST | NR |
 | / | NR | 3-5 W; 6-12 W; 13-20 W | YES/YES | NR | Cellsearch | 17/320; 18/336; 16/254 | NR | mCRC | PFS,OS(3) | PFS,OS, RECIST | NR |
Yen 2009 [37] | 76(44/32) | 55/21 | NR | NR | 64(39–83) | membrane-array | 30/76 | 20(4–34) | mCRC | PFS,OS(3) | PFS,OS, RECIST | YES |
Cohen 2008 [11] | 430(238/192) | 292/71/66 | baseline | NO/YES | 64(22–92) | Cellsearch | 107/413 | 12.6 ± 6.5/11.0(0.8-30.0) | mCRC | PFS,OS(11) | PFS,OS, RECIST | NR |
 | / | NR | 3-5 W | YES/YES | NR | Cellsearch | 38/320 | NR | mCRC | PFS,OS(11) | PFS,OS, RECIST | NR |
 | / | NR | 1-2 W; 6-12 W; 13-20 W | YES/YES | NR | Cellsearch | 41/357; 25/310; 21/193 | NR | mCRC | PFS,OS(11) | PFS,OS, RECIST | NR |
Staritz 2004 [31] | 42 | NR | baseline | NO/YES | NR | RT-PCR | 19/41 | 13.7(1.9-25.4) | mCRC | OS(10) | OS | NR |
 |  |  | 1 day | YES/YES | NR | RT-PCR | 23/40 | 13.7(1.9-25.4) | mCRC | OS(10) | OS | NR |