Prognostic impact of urokinase-type plasminogen activator system components in clear cell renal cell carcinoma patients without distant metastasis

Table 4 Associations of combinations of uPA system components in tumour tissue specimens with disease-specific survival (DSS) and overall survival (OS) of patients with ccRCC (n = 112) assessed by multivariate Cox’s regression analysis

Factor	No. cases	Disease-specific survival HR (95% CI)^a	P	Overall survival HR (95% CI)^a	P
uPA/uPAR ^b
uPA and uPAR low	41	1		1
uPA and/or uPAR high	71	14.5 (1.88-111.1)	0.010	1.34 (0.64-2.82)	0.438
uPA/PAI-1 ^b
uPA and PAI-1 low	43	1		1
uPA and/or PAI-1 high	69	4.24 (1.21-14.9)	0.024	1.63 (0.78-3.40)	0.196
uPAR/PAI-1 ^b
uPAR and PAI-1 low	40	1		1
uPAR and/or PAI-1 high	72	3.47 (0.98-12.2)	0.053	1.56 (0.73-3.36)	0.255

^aHR: hazard ratio; 95% CI: 95% confidence interval of multivariate Cox’s regression analysis; combinations of uPA system factors were separately added to the base model consisting of gender, age, tumour stage and tumour grade.
^bDichotomised into groups with high and low levels of uPA system factors by the median values.

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