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Table 3 Associations of uPA system components in tumour tissue specimens with disease-specific survival (DSS) and overall survival (OS) of patients with ccRCC (n = 112) assessed by multivariate Cox’s regression analysis

From: Prognostic impact of urokinase-type plasminogen activator system components in clear cell renal cell carcinoma patients without distant metastasis

Factor

No. cases

Disease-specific survival HR (95% CI)a

P

Overall survival HR (95% CI)a

P

Gender

     

male

65

1

 

1

 

female

47

0.93 (0.38-2.28)

0.880

1.65 (0.79-3.45)

0.179

Age (years)

     

≤64

57

1

 

1

 

>64

55

2.31 (0.89-5.99)

0.085

2.52 (1.26-5.07)

0.009

Tumour stage

     

pT1+2

87

1

 

1

 

pT3+4

25

1.85 (0.73-4.69)

0.192

1.17 (0.56-2.44)

0.670

Tumour grade

     

G1+2

68

1

 

1

 

G3+4

44

2.08 (0.83-5.19)

0.118

1.61 (0.82-3.14)

0.165

uPA b

     

low

53

1

 

1

 

high

59

2.86 (1.07-7.67)

0.037

1.28 (0.66-2.51)

0.467

uPAR b

     

low

55

1

 

1

 

high

57

4.70 (1.51-14.6)

0.008

1.60 (0.80-3.23)

0.185

PAI-1 b

     

low

56

1

 

1

 

high

56

2.59 (0.95-7.08)

0.064

1.71 (0.85-3.46)

0.135

  1. aHR: hazard ratio; 95% CI: 95% confidence interval of multivariate Cox’s regression analysis; uPA system factors were separately added to the base model consisting of gender, age, tumour stage and tumour grade.
  2. bDichotomised into groups with high and low levels of uPA system factors by the median values.