Figure 1

Immunohistochemical E-cadherin expression in oral normal mucosa, oral leukoplakia and oral cavity squamous cell carcinoma. (A, B) intense membranous E-cadherin expression in the basal and parabasal layers in normal oral mucosa; (C, D) show reduced E-cadherin expression in the parabasal layer in low risk oral leukoplakia; (E, F) illustrate the decrease in E-cadherin expression in all oral epithelial layers in high risk oral leukoplakia; (G, H) show a moderately differentiated OCSCC with loss of E-cadherin expression in the cell membrane of the neoplastic cells in the tumor invasion front; cytoplasmic and nuclear staining were observed (arrow); (I, J) Negative control. Immunohistochemical staining, original magnifications; x200 (A, C, E, G, I) and x400 (B, D, F, H, J).