Figure 8

Immune accelerators acting on remaining tumor after debulking surgery induce a systemic anti-tumor response capable of attacking local residual tumor. In cases of incomplete debulking surgery, local delivery of IMQ into the tumor site combined with systemic delivery of activating anti-CD40 is an effective approach to promote DC activation and cross-priming of CD8 T cells, leading to a systemic anti-tumor response capable of attacking residual primary tumor deposits and, potentially, secondary metastatic deposits.