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Table 3 Current and recent perioperative chemotherapy phase III trials for MIBC

From: Current and recent clinical trials for perioperative systemic therapy for muscle invasive bladder cancer: a systematic review

Institution Regimen Setting Status/Results Trial ID
University Hospital, Rouen HD-MVAC vs. GC Neoadjuvant or Adjuvant Recruiting participants. NCT01812369
Southwest Oncology Group DD-MVAC vs. GC Neoadjuvant Recruiting participants [21].  
Japan Clinical Oncology Group MVAC vs. Immediate RC Neoadjuvant Completed. 130 total subjects. OS increased by 35% in MVAC arm (64 subjects) but was not statistically significant. Improved pT0 rate with MVAC [22].  
FTRC GC vs. Immediate RC Adjuvant Completed. 192 total subjects. No difference between adjuvant treatment (102) and control arms for 5 year OS. Failed to reach accrual goal, low study power [23]. NCT00054626
Cairo University GC + radiotherapy vs. radiotherapy alone Adjuvant Completed. 146 total subjects. Improvement in 45-month DFS from 28% to 70% in chemoradiotheraphy (72) group but failed to be statistically significant [24]. NCT01734798
Eastern Cooperative Oncology Group MVAC vs. PCa Adjuvant Completed. Results unreported. NCT00003701
Sun Yat-Sen University Intraarterial GC Adjuvant Recruiting Participants. NCT01627197
Association of Urogenital Oncology Adjuvant vs. Progression-Triggered Gemcitabine Adjuvant Completed. 114 total subjects. No statistically significant difference between adjuvant or progression-triggered Gemcitabine for DFS or OS. Failed to reach accrual goal [25]. NCT00146276
EORTC Adjuvant vs. Progression Triggered MVAC + Gemcitabine Adjuvant Closed early due to poor accrual NCT00028756
  1. FTRC = Fondazione C.N.R./Regione Toscana “G. Monasterio”, Pisa, Italy. EORTC = European Organisation of Research and Treatment of Cancer. GC = Gemcitabine + Cisplatin. MVAC = Methotrexate + Vinblastine + Doxorubicin + Cisplatin. RC = Radical Cystectomy. PCa = Paclitaxel + Carboplatin. HD = High Dose. DD = Dose Dense. OS = Overall Survival. DFS = Disease Free Survival.