Table 2 Enriched KEGG pathways of predicted targets for the six miRNAs (miR-370, miR-210, miR-320a, miR-124, miR-107 and miR-486-5p) in cluster 3
KEGG pathway | P value | Number of genes | Genes |
|---|---|---|---|
Hedgehog signalling | 0.009 | 14 | BMP2, BMP6, BTRC, CSNK1A1, CSNK1E, CSNK1G3, GLI3, IHH, LRP2, RAB23, SMO, SUFU, WNT16, WNT3A |
Glioma | 0.010 | 11 | AKT3, CDK4, CDK6, E2F3, IGF1, IGF1R, MAPK1, PIK3CA, PIK3R1, PTEN, SOS2 |
Melanoma | 0.010 | 15 | AKT3, CDK4, CDK6, E2F3, FGF19, FGF2, FGF7, IGF1, IGF1R, MAPK1, PDGFC, PDGFD, PIK3CA, PIK3R1, PTEN |
Prostate cancer | 0.010 | 18 | AKT3, CCNE1, CREB3, CREB3L2, CREB5, CTNNB1, E2F3, FOXO1A, IGF1, IGF1R, LEF1, MAPK1, PDGFC, PDGFD, PIK3CA, PIK3R1, PTEN, SOS2 |
Focal adhesion | 0.014 | 30 | AC128683.3, AKT3, ARHGAP5, COL4A1, CRKL, CTNNB1, IGF1, IGF1R, ITGA1, ITGA2, ITGA4, ITGB8, LAMC1, MAPK1, MAPK8, MYL12A, PDGFC, PDGFD, PIK3CA, PIK3R1, PPP1R12A, PTEN, RAC1, RAP1A, RAPGEF1, SOS2, VAV3, VCL, XIAP, ZYX |
Pathways in cancer | 0.014 | 43 | AKT3, ARNT, AXIN2, BMP2, CBL, CCNE1, CDK4, CDK6, COL4A1, CRKL, CTNNB1, DVL1, E2F3, EVI1, FGF19, FGF2, FGF7, FOXO1A, GLI3, IGF1, IGF1R, ITGA2, KITLG, LAMC1, LEF1, MAPK1, MAPK8, PIK3CA, PIK3R1, PTEN, RAC1, RASSF5, RET, RUNX1T1, SMO, SOS2, STK4, SUFU, TPM3, VHL, WNT16, WNT3A, XIAP |
Circadian rhythm - mammal | 0.015 | 6 | ASH1L, EHHADH, MLL5, SETD1B, SUV420H1, WHSC1 |
mTOR signalling | 0.017 | 12 | AC026713.5, AKT3, CAB39, EIF4B, IGF1, MAPK1, PIK3CA, PIK3R1, PRKAA2, RPS6KA3, TSC1, ULK1 |
Adipocytokine signalling | 0.038 | 10 | ADIPOR1, AKT3, JAK2, LEPR, MAPK8, PPARGC1A, PRKAA2, PRKAB2, PRKAG2, PRKAG3 |
Lysine degradation | 0.040 | 6 | ASH1L, EHHADH, MLL5, SETD1B, SUV420H1, WHSC1 |
Insulin signalling | 0.041 | 21 | AKT3, CBL, CRKL, FASN, FOXO1A, INSR, MAPK1, MAPK8, PDE3B, PHKA1, PIK3CA, PIK3R1, PPARGC1A, PRKAA2, PRKAB2, PRKAG2, PRKAG3, RAPGEF1, SKIP, SOS2, TSC1 |
Endometrial cancer | 0.049 | 9 | AKT3, AXIN2, CTNNB1, LEF1, MAPK1, PIK3CA, PIK3R1, PTEN, SOS2 |
Cytokine-cytokine receptor interaction | 0.049 | 18 | ACVR2A, ACVR2B, BMP2, BMPR1A, BMPR2, CCL21, CCR7, CCR8, CXCR5, IL1RAP, IL23R, IL4R, IL6ST, IL9R, KITLG, LEPR, LIFR, PDGFC |