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Table 2 Enriched KEGG pathways of predicted targets for the six miRNAs (miR-370, miR-210, miR-320a, miR-124, miR-107 and miR-486-5p) in cluster 3

From: MicroRNA in exosomes isolated directly from the liver circulation in patients with metastatic uveal melanoma

KEGG pathway P value Number of genes Genes
Hedgehog signalling 0.009 14 BMP2, BMP6, BTRC, CSNK1A1, CSNK1E, CSNK1G3, GLI3, IHH, LRP2, RAB23, SMO, SUFU, WNT16, WNT3A
Glioma 0.010 11 AKT3, CDK4, CDK6, E2F3, IGF1, IGF1R, MAPK1, PIK3CA, PIK3R1, PTEN, SOS2
Melanoma 0.010 15 AKT3, CDK4, CDK6, E2F3, FGF19, FGF2, FGF7, IGF1, IGF1R, MAPK1, PDGFC, PDGFD, PIK3CA, PIK3R1, PTEN
Prostate cancer 0.010 18 AKT3, CCNE1, CREB3, CREB3L2, CREB5, CTNNB1, E2F3, FOXO1A, IGF1, IGF1R, LEF1, MAPK1, PDGFC, PDGFD, PIK3CA, PIK3R1, PTEN, SOS2
Focal adhesion 0.014 30 AC128683.3, AKT3, ARHGAP5, COL4A1, CRKL, CTNNB1, IGF1, IGF1R, ITGA1, ITGA2, ITGA4, ITGB8, LAMC1, MAPK1, MAPK8, MYL12A, PDGFC, PDGFD, PIK3CA, PIK3R1, PPP1R12A, PTEN, RAC1, RAP1A, RAPGEF1, SOS2, VAV3, VCL, XIAP, ZYX
Pathways in cancer 0.014 43 AKT3, ARNT, AXIN2, BMP2, CBL, CCNE1, CDK4, CDK6, COL4A1, CRKL, CTNNB1, DVL1, E2F3, EVI1, FGF19, FGF2, FGF7, FOXO1A, GLI3, IGF1, IGF1R, ITGA2, KITLG, LAMC1, LEF1, MAPK1, MAPK8, PIK3CA, PIK3R1, PTEN, RAC1, RASSF5, RET, RUNX1T1, SMO, SOS2, STK4, SUFU, TPM3, VHL, WNT16, WNT3A, XIAP
Circadian rhythm - mammal 0.015 6 ASH1L, EHHADH, MLL5, SETD1B, SUV420H1, WHSC1
mTOR signalling 0.017 12 AC026713.5, AKT3, CAB39, EIF4B, IGF1, MAPK1, PIK3CA, PIK3R1, PRKAA2, RPS6KA3, TSC1, ULK1
Adipocytokine signalling 0.038 10 ADIPOR1, AKT3, JAK2, LEPR, MAPK8, PPARGC1A, PRKAA2, PRKAB2, PRKAG2, PRKAG3
Lysine degradation 0.040 6 ASH1L, EHHADH, MLL5, SETD1B, SUV420H1, WHSC1
Insulin signalling 0.041 21 AKT3, CBL, CRKL, FASN, FOXO1A, INSR, MAPK1, MAPK8, PDE3B, PHKA1, PIK3CA, PIK3R1, PPARGC1A, PRKAA2, PRKAB2, PRKAG2, PRKAG3, RAPGEF1, SKIP, SOS2, TSC1
Endometrial cancer 0.049 9 AKT3, AXIN2, CTNNB1, LEF1, MAPK1, PIK3CA, PIK3R1, PTEN, SOS2
Cytokine-cytokine receptor interaction 0.049 18 ACVR2A, ACVR2B, BMP2, BMPR1A, BMPR2, CCL21, CCR7, CCR8, CXCR5, IL1RAP, IL23R, IL4R, IL6ST, IL9R, KITLG, LEPR, LIFR, PDGFC