Figure 6
From: Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway
Fenofibrate slow down the growth of xenograft model of triple-negative breast cancer by inducing apoptosis. (A) Tumor volume with days after treatment. The volumes of tumors in the two groups reached a significant difference 15 days after fenofibrate treatment (** indicates p < 0.01 relative to the control group). (B, C) The tumor sizes in the treatment group were significantly smaller than that of the control group at the end of the study. (D, E) The tumor weight and the percentage of tumor weight/ mice body weight of the treatment group were significantly lighter than that of the control group (** indicates p < 0.01 relative to the control group). (F, G) The analysis of paraffin-embedded human breast cancer tissue from nude mouse models by TUNEL assay. Compared with the control group, TUNEL assay showed an increased number of apoptotic cells in fenofibrate treatment group (** indicates p < 0.01 relative to the control group). Feno = fenofibrate, Con = control.