Fenofibrate alters cell cycle of MDA-MB-231 cells. (A, B) Treatment with fenofibrate led to cell cycle arrest of MDA-MB-231 cells at G0/G1 phase. (C) Fenofibrate exposure caused a time- and dose-dependent decrease of Cyclin D1 and Cdk4 and increase of p21 and p27/Kip1 while the expressions of p53, Cdk2, Cdk6 and Cyclin B1 remained unchanged. (A, C) All the experiments were repeated three times and the representative ones of those results were shown. (B) Data represent the means ± SD of three independent experiments. Feno = fenofibrate, Con = control, *indicates p < 0.05.