Figure 2
From: Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway
Fenofibrate induces apoptosis of MDA-MB-231 cells. (A, B) Fenofibrate induced apoptosis of MDA-MB-231 cells in a time- and dose-dependent manner. (C) Western blot analysis confirmed that fenofibrate dramatically up-regulated the expression of Bad and down-regulated the expressions of Bcl-xl and Survivin and finally induced cleavage of caspase-3, but had no impact on BID and Bcl-2. (A, C) All the experiments were repeated three times and the representative ones of those results were shown. (B) Data represent the means ± SD of three independent experiments. Feno = fenofibrate, Con = control, *indicates p < 0.05, **indicates p < 0.01, ***indicates p < 0.001.