Expression of matrix metalloproteinases and their inhibitors in different immunohistochemical-based molecular subtypes of breast cancer

Table 3 Multivariate analysis with Cox’s proportional hazards model for prognostic factors in breast cancer patients

	Overall survival			Disease-free survival
	HR	95% CI	P-value^*	HR	95% CI	P-value^*
Tumor size (≤2 or >2 cm)	2.873	0.85-9.73	0.090	3.153	0.93-10.71	0.066
Lymph node status (negative or positive)	1.088	0.45-2.62	0.851	1.988	0.83-4.75	0.122
Stage (I, II or III)	4.454	2.46-8.06	0.000	3.577	1.926-6.643	0.000
Stromal MMP-1 expression (negative or positive)	0.528	0.29-0.98	0.042	-	-	-
Tumor TIMP-3 expression (negative or positive)	-	-	-	3.003	0.71-12.63	0.133

* Multivariate analysis was carried out on all variables that were found to be significant in univariate analysis.
HR, hazard rate; CI, confidence interval; -, not significant in univariate analysis.

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