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Table 3 Multivariate analysis with Cox’s proportional hazards model for prognostic factors in breast cancer patients

From: Expression of matrix metalloproteinases and their inhibitors in different immunohistochemical-based molecular subtypes of breast cancer

  Overall survival Disease-free survival
HR 95% CI P-value* HR 95% CI P-value*
Tumor size (≤2 or >2 cm) 2.873 0.85-9.73 0.090 3.153 0.93-10.71 0.066
Lymph node status (negative or positive) 1.088 0.45-2.62 0.851 1.988 0.83-4.75 0.122
Stage (I, II or III) 4.454 2.46-8.06 0.000 3.577 1.926-6.643 0.000
Stromal MMP-1 expression (negative or positive) 0.528 0.29-0.98 0.042 - - -
Tumor TIMP-3 expression (negative or positive) - - - 3.003 0.71-12.63 0.133
  1. * Multivariate analysis was carried out on all variables that were found to be significant in univariate analysis.
  2. HR, hazard rate; CI, confidence interval; -, not significant in univariate analysis.