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Table 5 Cox proportional univariate and multivariate analysis of the association between prognostic variables and overall and disease-free survival in cervical cancer

From: MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer

  Disease-free Survival hazard ratio [95% CI], Pvalue Overall Survival hazard ratio [95% CI], Pvalue
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
FIGO stage 5.32 [2.75-10.30], <0.001 3.60 [1.36-9.55], 0.010 3.97 [1.65-9.54], 0.002 2.77 [1.13-7.76], 0.025
Tumor grade (poor) 1.65 [0.85-3.22], 0.137 NA 2.15 [0.89-5.21], 0.087 NA
Tumor size (>4 cm) 2.13 [1.09-4.14], 0.025 1.16 [0.47-2.90], 0.737 1.90 [0.78-4.65], 0.157 NA
LN metastasis 4.53 [2.14-9.61], <0.001 2.71 [1.08-6.79], 0.032 2.25 [0.77-6.59], 0.136 NA
HPV+ 0.68 [0.08-5.21], 0.710 NA 0.38 [0.048-3.10], 0.370 NA
MICA/B+ 0.43 [0.20-0.92], 0.032 0.54 [0.20-1.41], 0.213 0.53 [0.20-1.36], 0.189 NA
ULBP1+ 0.36 [0.16-0.80], 0.012 0.31 [0.11-0.86], 0.024 0.21 [0.06-0.73], 0.014 0.27 [0.07-0.97], 0.044
RAET1E+ 2.17 [1.12-4.2], 0.021 1.90 [0.84-4.32], 0.123 1.03 [0.41-2.60], 0.935 NA
RAET1G+ 2.09 [1.05-4.15], 0.034 1.62 [0.68-3.87], 0.275 1.69 [0.70-4.09], 0.240 NA
MICA/B+/ULBP1+ 0.11 [0.02-0.45], 0.002 0.16 [0.03-0.70], 0.015 0.026 [0.00-1.17], 0.060 NA
  1. IHC staining scores of NKG2DLs were dichotomized into low (-) expression (≤ mean score of cancer specimens) and high (+) expression (> mean score of cancer specimens).
  2. FIGO, International Federation of Gynecology and Obstetrics; LN, lymph node; HPV, human papilloma virus; CI, confidence interval; NA, not applicable.