Table 2 IHC scores of NKG2DLs MICA/B, ULBP1, ULBP2, ULBP3, RAET1E, and RAET1G in 1,167 TMA specimens
From: MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer
| Â | Number | % | Mean score | 95% CI | Â | pvalue | |
|---|---|---|---|---|---|---|---|
Lower | Upper | ||||||
MICA/B | Normal | 457 | 45.2 | 4.83 | 4.62 | 5.04 | <0.001 |
Low-grade CIN | 90 | 8.9 | 4.89 | 4.53 | 5.25 | Â | |
High-grade CIN | 270 | 26.7 | 6.30 | 6.00 | 6.61 | Â | |
Cancer | 195 | 19.3 | 6.78 | 6.43 | 7.13 | Â | |
Total | 1012 | 100.0 | 5.60 | 5.45 | 5.76 | Â | |
ULBP1 | Normal | 500 | 45.9 | 4.82 | 4.64 | 5.00 | <0.001 |
Low-grade CIN | 92 | 8.4 | 5.54 | 5.14 | 5.94 | Â | |
High-grade CIN | 314 | 28.8 | 6.05 | 5.78 | 6.32 | Â | |
Cancer | 183 | 16.8 | 6.66 | 6.27 | 7.04 | Â | |
Total | 1089 | 100.0 | 5.54 | 5.40 | 5.68 | Â | |
ULBP2 | Normal | 458 | 43.5 | 3.47 | 3.30 | 3.65 | 0.001 |
Low-grade CIN | 93 | 8.8 | 4.23 | 3.82 | 4.63 | Â | |
High-grade CIN | 318 | 30.2 | 3.94 | 3.73 | 4.16 | Â | |
Cancer | 184 | 17.5 | 3.71 | 3.40 | 4.02 | Â | |
Total | 1053 | 100.0 | 3.72 | 3.60 | 3.84 | Â | |
ULBP3 | Normal | 455 | 44.0 | 5.22 | 5.02 | 5.41 | 0.017 |
Low-grade CIN | 93 | 9.0 | 5.84 | 5.37 | 6.31 | Â | |
High-grade CIN | 307 | 29.7 | 5.34 | 5.05 | 5.63 | Â | |
Cancer | 180 | 17.4 | 4.91 | 4.56 | 5.26 | Â | |
Total | 1035 | 100.0 | 5.26 | 5.11 | 5.40 | Â | |
RAET1E | Normal | 461 | 44.4 | 3.57 | 3.47 | 3.68 | <0.001 |
Low-grade CIN | 94 | 9.1 | 3.77 | 3.54 | 3.99 | Â | |
High-grade CIN | 302 | 29.1 | 3.76 | 3.62 | 3.91 | Â | |
Cancer | 181 | 17.4 | 4.38 | 4.12 | 4.65 | Â | |
Total | 1038 | 100.0 | 3.79 | 3.71 | 3.87 | Â | |
RAET1G | Normal | 470 | 44.2 | 5.11 | 4.95 | 5.27 | 0.001 |
Low-grade CIN | 95 | 8.9 | 5.17 | 4.83 | 5.50 | Â | |
High-grade CIN | 314 | 29.5 | 4.61 | 4.39 | 4.82 | Â | |
Cancer | 184 | 17.3 | 5.11 | 4.78 | 5.45 | Â | |
Total | 1063 | 100.0 | 4.97 | 4.85 | 5.08 | Â | |