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Table 2 IHC scores of NKG2DLs MICA/B, ULBP1, ULBP2, ULBP3, RAET1E, and RAET1G in 1,167 TMA specimens

From: MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer

  Number % Mean score 95% CI   pvalue
Lower Upper
MICA/B Normal 457 45.2 4.83 4.62 5.04 <0.001
Low-grade CIN 90 8.9 4.89 4.53 5.25  
High-grade CIN 270 26.7 6.30 6.00 6.61  
Cancer 195 19.3 6.78 6.43 7.13  
Total 1012 100.0 5.60 5.45 5.76  
ULBP1 Normal 500 45.9 4.82 4.64 5.00 <0.001
Low-grade CIN 92 8.4 5.54 5.14 5.94  
High-grade CIN 314 28.8 6.05 5.78 6.32  
Cancer 183 16.8 6.66 6.27 7.04  
Total 1089 100.0 5.54 5.40 5.68  
ULBP2 Normal 458 43.5 3.47 3.30 3.65 0.001
Low-grade CIN 93 8.8 4.23 3.82 4.63  
High-grade CIN 318 30.2 3.94 3.73 4.16  
Cancer 184 17.5 3.71 3.40 4.02  
Total 1053 100.0 3.72 3.60 3.84  
ULBP3 Normal 455 44.0 5.22 5.02 5.41 0.017
Low-grade CIN 93 9.0 5.84 5.37 6.31  
High-grade CIN 307 29.7 5.34 5.05 5.63  
Cancer 180 17.4 4.91 4.56 5.26  
Total 1035 100.0 5.26 5.11 5.40  
RAET1E Normal 461 44.4 3.57 3.47 3.68 <0.001
Low-grade CIN 94 9.1 3.77 3.54 3.99  
High-grade CIN 302 29.1 3.76 3.62 3.91  
Cancer 181 17.4 4.38 4.12 4.65  
Total 1038 100.0 3.79 3.71 3.87  
RAET1G Normal 470 44.2 5.11 4.95 5.27 0.001
Low-grade CIN 95 8.9 5.17 4.83 5.50  
High-grade CIN 314 29.5 4.61 4.39 4.82  
Cancer 184 17.3 5.11 4.78 5.45  
Total 1063 100.0 4.97 4.85 5.08