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Figure 7 | BMC Cancer

Figure 7

From: Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells

Figure 7

Schematic diagram illustrating the potential of secreted substances from breast cancer-associated fibroblasts (BCFs) to induce expression of intracellular HMGB1 in breast cancer cells. After exposure to a chemotherapeutic agent, in this case doxorubicin, (Dox), this increased intracellular HMGB1 can be released and may function in a paracrine manner to induce acquired chemoresistance of the nearby surviving cancer cells.

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