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Table 4 Association of COX-2 immunostaining status (intensity 3 vs 0-2) with breast cancer specific overall survival (OS) in the Mainz cohort of node negative breast cancer patients (n = 193)

From: Prognostic influence of cyclooxygenase-2 protein and mRNA expression in node-negative breast cancer patients

A. Univariate Cox analysis

Prognostic factor

p

HR

95% CI

COX-2 immunostaining status

0.043

2.128

1.023-4.427

B. Multivariate Cox analysis

Prognostic factors

p

HR

95% CI

Age

0.984

0.991

0.418-2.350

(<50 vs ≥50 years)

pT stage

0.547

1.262

0.592-2.693

(≤2cm vs >2cm)

Histological grade

   

(Grade 3 vs grade 1 and 2)

<0.001

5.331

2.325-12.223

HR1 (ER or PR)

0.812

0.903

0.391-2.089

(Negative vs. positive)

HER-2 status

0.290

1.592

0.672-3.770

(Positive vs negative)

COX-2 immunostaining status

0.096

1.929

0.889-4.187

  1. 1The hormone receptor status (HR) is positive as soon as one of both, the estrogen (ER) or the progesterone receptor status (PR), is positive.
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BMC Cancer

ISSN: 1471-2407

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