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Table 4 Association of COX-2 immunostaining status (intensity 3 vs 0-2) with breast cancer specific overall survival (OS) in the Mainz cohort of node negative breast cancer patients (n = 193)

From: Prognostic influence of cyclooxygenase-2 protein and mRNA expression in node-negative breast cancer patients

A. Univariate Cox analysis
Prognostic factor p HR 95% CI
COX-2 immunostaining status 0.043 2.128 1.023-4.427
B. Multivariate Cox analysis
Prognostic factors p HR 95% CI
Age 0.984 0.991 0.418-2.350
(<50 vs ≥50 years)
pT stage 0.547 1.262 0.592-2.693
(≤2cm vs >2cm)
Histological grade    
(Grade 3 vs grade 1 and 2) <0.001 5.331 2.325-12.223
HR1 (ER or PR) 0.812 0.903 0.391-2.089
(Negative vs. positive)
HER-2 status 0.290 1.592 0.672-3.770
(Positive vs negative)
COX-2 immunostaining status 0.096 1.929 0.889-4.187
  1. 1The hormone receptor status (HR) is positive as soon as one of both, the estrogen (ER) or the progesterone receptor status (PR), is positive.