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Table 3 Association of COX-2 immunostaining status (intensity score 3 vs 0-2) with breast cancer specific metastasis-free survival (MFS) in the Mainz cohort of node negative breast cancer patients (n = 193)

From: Prognostic influence of cyclooxygenase-2 protein and mRNA expression in node-negative breast cancer patients

A. Univariate Cox analysis
Prognostic factor p HR 95% CI
COX-2 intensity score 0.002 2.582 1.418-4.703
B. Multivariate Cox analysis
Prognostic factors p HR 95% CI
Age 0.693 0.869 0.432-1.747
(<50 vs ≥50 years)
pT stage 0.287 1.411 0.749-2.658
(≤2cm vs >2cm)
Histological grade    
(Grade 3 vs grade 1 and 2) <0.001 4.315 2.275-8.182
HR1 (ER or PR) 0.888 0.951 0.471-1.920
(negative vs. positive)
HER-2 status 0.122 1.798 0.855-3.783
(positive vs negative)
COX-2 intensity score 0.002 2.70 1.469-5.263
  1. 1The hormone receptor status (HR) is positive as soon as one of both, the estrogen (ER) or the progesterone receptor status (PR), is positive.