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Table 2 Association of COX-2 immunostaining status (intensity 3 vs 0-2) with breast cancer specific disease-free survival (DFS) in the Mainz cohort of node negative breast cancer patients (n = 193)

From: Prognostic influence of cyclooxygenase-2 protein and mRNA expression in node-negative breast cancer patients

A. Univariate Cox analysis
Prognostic factor p HR 95% CI
COX-2 immunostaining status 0.001 2.427 1.426-4.131
B. Multivariate Cox analysis
Prognostic factors p HR 95% CI
Age 0.467 0.802 0.443-1.452
(<50 vs ≥50 years)
pT stage 0.815 1.068 0.614-1.861
(≤2cm vs >2cm)
Histological grade    
(Grade 3 vs grade 1 and 2) <0.001 4.510 2.562-7.940
HR1 (ER or PR) 0.523 0.813 0.431-1534
(negative vs. positive)
HER-2 status 0.498 1.273 0.633-2.559
(positive vs negative)
COX-2 immunostaining status <0.001 2.767 1.563-4.901
  1. 1The hormone receptor status (HR) is positive as soon as one of both, the estrogen (ER) or the progesterone receptor status (PR), is positive.