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Table 1 Characteristics of studies included in the meta-analysis

From: Association between HIF-1α C1772T/G1790A polymorphisms and cancer susceptibility: an updated systematic review and meta-analysis based on 40 case-control studies

First author Year Country Ethnicity Cancer type Gene type Source of controls Cases Controls Case Control HWE
          MM MW WW MM MW WW  
Clifford 2001 UK Caucasian Renal C1772T PB 48 143 42 6 0 110 27 6 0.02
      G1790A PB 48 144 47 1 0 140 4 0 0.87
Tanimoto 2003 Japan Asian HNSCC C1772T PB 55 110 45 10 0 98 12 0 0.55
      G1790A PB 55 110 51 4 0 101 9 0 0.65
Kuwai 2004 Japan Asian Colorectal C1772T PB 100 100 100 0 0 89 11 0 0.56
Ollerenshaw 2004 UK Caucasian Renal C1772T PB 160 162 16 54 90 1 90 71 0.001
      G1790A PB 146 288 65 67 14 239 39 10 0.001
Ling 2005 China Asian Esophageal C1772T HB 95 104 84 11 0 93 11 0 0.57
Chau 2005 USA Caucasian Prostate C1772T PB 196 196 161 29 6 179 14 3 0.002
Fransen 2006 Sweden Caucasian Colorectal C1772T PB 198 258 167 28 3 213 43 2 0.92
Fransen 2006 Sweden Caucasian Colorectal G1790A PB 198 256 189 9 0 247 9 0 0.77
Konac 2007 Turkey Caucasian Cervical C1772T HB 32 107 10 14 8 68 37 2 0.23
      G1790A HB 32 107 32 0 0 107 0 0 0.99
    Caucasian Ovarian C1772T HB 49 107 34 14 1 68 37 2 0.23
      G1790A HB 49 107 47 2 0 107 0 0 0.99
    Caucasian Endometrial C1772T HB 21 107 4 12 5 68 37 2 0.23
      G1790A HB 21 107 21 0 0 107 0 0 0.99
Li 2007 USA mixed Prostate C1772T PB 1041 1234 818 209 14 995 221 18 0.16
      G1790A PB 1066 1264 1053 13 0 1247 17 0 0.81
Orr-Urtreger 2007 Israel Caucasian Prostate C1772T PB 402 300 287 99 16 217 80 3 0.14
      G1790A PB 200 300 198 2 0 298 2 0 0.95
Apaydin 2008 Turkey Caucasian Breast C1772T PB 102 102 79 21 2 68 29 5 0.42
      G1790A PB 102 102 102 0 0 98 4 0 0.84
Lee 2008 Korea Asian Breast C1772T PB 1332 1369 1207 119 6 1245 123 1 0.25
Kim 2008 Korea Asian Breast C1772T HB 90 102 81 8 1 93 9 0 0.64
      G1790A HB 90 102 87 3 0 94 7 1 0.06
Nadaoka 2008 Japan Asian Bladder C1772T HB 219 461 197 21 1 419 42 0 0.35
      G1790A HB 219 461 204 13 2 421 40* - 0.46
Jacobs 2008 USA mixed Prostate C1772T HB 1420 1450 1156 252 12 1138 284 28 0.04
Horree 2008 Netherland Caucasian Endometrial C1772T PB 58 559 50 5 3 463 84 12 0.01
Naidu 2009 Malaysia Asian Breast C1772T PB 410 275 294 100 16 222 50 3 0.92
      G1790A PB 410 275 332 72 6 232 41 2 0.90
Chen 2009 Taiwan Asian Oral C1772T PB 174 347 163 10 1 334 13 0 0.72
      G1790A PB 174 347 153 20 1 333 14 0 0.70
Konac 2009 Turkey Caucasian Lung C1772T PB 141 156 110 31 0 111 43 2 0.34
      G1790A PB 141 156 141 1 0 154 2 0 0.94
Morris 2009 UK Caucasian Renal C1772T PB 332 313 290 39 3 262 46 5 0.08
      G1790A PB 325 309 313 10 2 294 15 0 0.66
Foley 2009 Ireland Caucasian Prostate C1772T PB 95 188 65 30 0 175 13 0 0.62
Li 2009 China Asian Gastric C1772T HB 87 106 83 4 0 93 13 0 0.50
      G1790A HB 87 106 74 13 0 100 6 0 0.76
Munoz-                
Guerra 2009 Spain Caucasian Oral C1772T PB 70 148 57 6 7 113 27 8 <0.01
      G1790A PB 64 139 40 21 3 130 9 0 0.69
Kim 2010 Korea Asian Cervical C1772T HB 199 214 177 22 0 187 27 0 0.32
      G1790A HB 199 213 187 12 0 200 12 1 0.10
Shieh 2010 Taiwan Asian Oral C1772T HB 305 96 282 23 0 89 7 0 0.71
      G1790A HB 305 96 281 24 0 89 7 0 0.71
Knechtal 2010 Austria Caucasian Colorectal C1772T PB 368 2156 291 77** - 1773 383* - >0.05
      G1790A PB 367 2156 356 11* - 2080 76* - >0.05
Hsiao 2010 Taiwan Asian Hepatocellul-ar C1772T HB 102 347 94 8 0 334 13 0 0.72
      G1790A HB 102 347 87 15 0 333 14 0 0.70
Xu 2011 China Asian Glioma C1772T HB 150 150 121 27 2 135 14 1 0.35
Putra 2011 Japan Asian Lung C1772T PB 83 110 74 9 0 98 12 0 0.55
      G1790A PB 83 110 72 9 2 101 9 0 0.65
Kang 2011 Korea Asian Colorectal C1772T PB 50 50 46 4** - 38 12** - <0.01
Wang 2011 China Asian Pancreatic C1772T HB 263 271 209 54 0 242 29 0 0.35
      G1790A HB 263 271 198 65 0 249 22 0 0.49
Zagouri 2012 Greece Caucasian Breast C1772T HB 113 124 98 15 0 107 17 0 0.41
Kuo 2012 Taiwan Asian Lung C1772T HB 285 300 153 94 38 216 73 11 0.13
      G1790A HB 285 300 150 94 41 215 74 11 0.15
Qin 2012 China Asian Renal C1772T HB 620 623 572 46 2 578 43 2 0.22
      G1790A HB 620 623 575 45 0 584 39 0 0.42
Li 2012 China Asian Prostate C1772T HB 662 716 612 48 2 659 57 0 0.27
      G1790A HB 662 716 614 47 1 685 31 0 0.55
Alves 2012 Brazil mixed Oral C1772T PB 40 88 0 1 39 0 85 3 <0.01
      G1790A PB 40 88 2 1 37 81 7 0 0.70
Ruiz-Tovar 2012 Spain Caucasian Pancreatic C1772T PB 59 152 47 1 11 116 28 8 0.002
      G1790A PB 59 152 54 2 3 142 10 0 0.68
Fu 2013 China Asian Cervical C1772T HB 518 553 467 49 2 492 60 1 0.55
      G1790A HB 509 553 489 20 0 510 42 1 0.89
Ribeiro 2013 Portugal Caucasian Breast C1772T PB 96 74 74 21 1 61 7 4 0.001
      G1790A PB 96 74 96 0 0 74 0 0 0.99
Mera-                
Menendez 2013 Spain Caucasian Glottic            
larynx C1772T HB 118 148 85 18 15 113 27 8 0.001     
      G1790A HB 111 139 107 4 0 130 9 0 0.69
Total      C1772T   10869 14289 8994 1568 307 12181 1897 211  
      G1790A   7117 10442 6416 589 112 9922 494 26  
  1. W: wide type alleles (1772C or 1790G); M: mutant type alleles (1772 T or 1790A); HWE: Hardy-Weinberg Equilibrium; PB: population based; HB: hospital based.
  2. Mixed: Caucasian and African-American; HNSCC: head and neck squamous cell carcinoma.
  3. *Frequency of genotypes “AA + AG”; **Frequency of genotypes “TT + TC”.