Treatment comparison | Platinum/Pemetrexed vs. Platinum/Docetaxel | Â | Â | Platinum/Pemetrexed vs. Platinum/Paclitaxel | Â | Â | Platinum/Pemetrexed vs. Platinum/Gemcitabine | Â | Â | Platinum/Pemetrexed vs. Platinum/Vinorelbine | Â | Â | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Matched pairs | 95 | RR | P value* | 118 | RR | P value* | 199 | RR | P value* | 72 | RR | P value* | ||||||||||||
All grades AE | N | % | N | % | Â | Â | N | % | N | % | Â | Â | N | % | N | % | Â | Â | N | % | N | % | Â | Â |
Hematological AE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Leukopenia | 29 | 30.5% | 27 | 28.4% | 1.074 | 0.752 | 34 | 28.8% | 39 | 33.1% | 0.872 | 0.508 | 64 | 32.2% | 84 | 42.2% | 0.762 | 0.041 | 18 | 25.0% | 27 | 37.5% | 0.667 | 0.106 |
Neutropenia | 24 | 25.3% | 19 | 20.0% | 1.263 | 0.336 | 29 | 24.6% | 35 | 29.7% | 0.829 | 0.396 | 63 | 31.7% | 57 | 28.6% | 1.105 | 0.540 | 12 | 16.7% | 23 | 31.9% | 0.522 | 0.034 |
Thrombocytopenia | 24 | 25.3% | 24 | 25.3% | 1.000 | 1.000 | 32 | 27.1% | 34 | 28.8% | 0.941 | 0.773 | 59 | 29.6% | 100 | 50.3% | 0.590 | <0.001 | 25 | 34.7% | 26 | 36.1% | 0.962 | 0.876 |
Anemia | 34 | 35.8% | 31 | 32.6% | 1.097 | 0.647 | 46 | 39.0% | 53 | 44.9% | 0.868 | 0.370 | 87 | 43.7% | 125 | 62.8% | 0.696 | <0.001 | 35 | 48.6% | 46 | 63.9% | 0.761 | 0.063 |
Any hematological AE | 56 | 58.9% | 58 | 61.1% | 0.966 | 0.752 | 70 | 59.3% | 80 | 67.8% | 0.875 | 0.189 | 130 | 65.3% | 163 | 81.9% | 0.798 | <0.001 | 47 | 65.3% | 58 | 80.6% | 0.810 | 0.056 |
Non-hematological AE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | 0.0% | Â | 0.0% | Â | Â |
Alopecia | 3 | 3.2% | 15 | 15.8% | 0.200 | 0.005 | 1 | 0.8% | 8 | 6.8% | 0.125 | 0.020 | 2 | 1.0% | 18 | 9.0% | 0.111 | <0.001 | 0 | 0.0% | 1 | 1.4% | 0.000 | 1.000 |
Arthralgia | 5 | 5.3% | 4 | 4.2% | 1.250 | 0.706 | 0 | 0.0% | 0 | 0.0% | — | — | 2 | 1.0% | 8 | 4.0% | 0.250 | 0.058 | 0 | 0.0% | 0 | 0.0% | — | — |
Cough | 1 | 1.1% | 2 | 2.1% | 0.500 | 0.564 | 1 | 0.8% | 1 | 0.8% | 1.000 | 1.000 | 3 | 1.5% | 12 | 6.0% | 0.250 | 0.020 | 2 | 2.8% | 1 | 1.4% | 2.000 | 0.564 |
Dermatitis | 0 | 0.0% | 0 | 0.0% | — | — | 0 | 0.0% | 0 | 0.0% | — | — | 0 | 0.0% | 0 | 0.0% | — | — | 0 | 0.0% | 0 | 0.0% | — | — |
Diarrhea | 1 | 1.1% | 2 | 2.1% | 0.500 | 0.317 | 1 | 0.8% | 0 | 0.0% | — | 1.000 | 3 | 1.5% | 0 | 0.0% | — | 0.250 | 2 | 2.8% | 3 | 4.2% | 0.667 | 0.655 |
Dyspnea | 1 | 1.1% | 0 | 0.0% | — | 1.000 | 1 | 0.8% | 0 | 0.0% | — | 1.000 | 3 | 1.5% | 6 | 3.0% | 0.500 | 0.317 | 1 | 1.4% | 0 | 0.0% | — | 1.000 |
Edema | 1 | 1.1% | 0 | 0.0% | — | 1.000 | 1 | 0.8% | 0 | 0.0% | — | 1.000 | 3 | 1.5% | 1 | 0.5% | 3.000 | 0.317 | 1 | 1.4% | 0 | 0.0% | — | 1.000 |
Fatigue | 11 | 11.6% | 11 | 11.6% | 1.000 | 1.000 | 10 | 8.5% | 27 | 22.9% | 0.370 | 0.001 | 18 | 9.0% | 62 | 31.2% | 0.290 | <0.001 | 13 | 18.1% | 23 | 31.9% | 0.565 | 0.048 |
Nausea | 63 | 66.3% | 67 | 70.5% | 0.940 | 0.527 | 78 | 66.1% | 84 | 71.2% | 0.929 | 0.446 | 134 | 67.3% | 148 | 74.4% | 0.905 | 0.122 | 53 | 73.6% | 53 | 73.6% | 1.000 | 1.000 |
Peripheral neuropathy | 1 | 1.1% | 3 | 3.2% | 0.333 | 0.317 | 0 | 0.0% | 5 | 4.2% | 0.000 | 0.063 | 3 | 1.5% | 2 | 1.0% | 1.500 | 0.657 | 1 | 1.4% | 2 | 2.8% | 0.500 | 0.564 |
Rash | 2 | 2.1% | 0 | 0.0% | — | 0.500 | 2 | 1.7% | 0 | 0.0% | — | 0.500 | 5 | 2.5% | 5 | 2.5% | 1.000 | 1.000 | 1 | 1.4% | 0 | 0.0% | — | 1.000 |
Stomatitis | 0 | 0.0% | 0 | 0.0% | — | — | 0 | 0.0% | 0 | 0.0% | — | — | 0 | 0.0% | 1 | 0.5% | 0.000 | 1.000 | 0 | 0.0% | 2 | 2.8% | 0.000 | 0.500 |
Vomiting | 40 | 42.1% | 47 | 49.5% | 0.851 | 0.286 | 51 | 43.2% | 52 | 44.1% | 0.981 | 0.895 | 92 | 46.2% | 94 | 47.2% | 0.979 | 0.849 | 31 | 43.1% | 37 | 51.4% | 0.838 | 0.366 |
Weight loss | 0 | 0.0% | 1 | 1.1% | 0.000 | 1.000 | 0 | 0.0% | 0 | 0.0% | — | — | 0 | 0.0% | 0 | 0.0% | — | — | 0 | 0.0% | 0 | 0.0% | — | — |