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Table 3 Multivariate Poisson regression models of SPC risk a by gender, France 1989–2004 (N = 289,967)

From: The effect of patient characteristics on second primary cancer risk in France

   Males Females
(N = 160,807) (N = 129,160)
   Ratio of SIRs P Ratio of EARs P Ratio of SIRs P Ratio of EARs P
   (95% CI)   (95% CI)   (95% CI)   (95% CI)  
Age at first cancer diagnosis ≤ 44 y 1.98 (1.78-2.20) <.001 0.63 (0.54-0.75) <.001 1.27 (1.15-1.41) <.001 0.54 (0.40-0.72) <.001
45 y-54 y 1.49 (1.41-1.59) 0.93 (0.84-1.04) 1.11 (1.03-1.20) 0.90 (0.72-1.13)
55 y-64 y 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
65 y-74 y 0.86 (0.82-0.89) 0.88 (0.78-1.00) 0.93 (0.87-0.99) 0.89 (0.69-1.14)
≥ 75 0.81 (0.77-0.85) 0.67 (0.53-0.84) 0.83 (0.77-0.89) 0.51 (0.32-0.81)
Year of first cancer diagnosis 1989-1994 1.00 (ref) .271 1.00 (ref) .037 1.00 (ref) .003 1.00 (ref) <.001
1995-1999 0.97 (0.93-1.01) 0.88 (0.79-0.97) 1.10 (1.04-1.17) 1.48 (1.19-1.84)
2000-2004 0.99 (0.95-1.03) 0.92 (0.82-1.04) 1.10 (1.03-1.18) 1.44 (1.10-1.89)
Follow-up ≥ 2 m- < 1 y 1.00 (0.95-1.06) <.001 0.82 (0.71-0.95) .037 1.05 (0.96-1.16) .284 0.93 (0.62-1.33) .006
≥ 1 y- < 2 y 1.00 (ref) 1.00 (ref) 1.00 (ref) 1.00 (ref)
≥ 2 y- < 4 y 0.99 (0.94-1.05) 1.02 (0.90-1.17) 1.02 (0.94-1.11) 1.03 (0.76-1.40)
≥ 4 y- < 6 y 0.96 (0.90-1.01) 0.96 (0.83-1.12) 1.00 (0.92-1.10) 1.07 (0.76-1.49)
≥ 6 y- < 8 y 0.95 (0.89-1.01) 1.01 (0.85-1.20) 1.07 (0.97-1.18) 1.41 (1.01-1.97)
≥ 8 y- < 10 y 0.90 (0.83-0.97) 0.90 (0.73-1.11) 1.00 (0.90-1.12) 1.31 (0.89-1.94)
≥ 10 y 0.82 (0.76-0.88) 0.87 (0.71-1.07) 1.10 (1.00-1.22) 1.83 (1.28-2.62)
First cancer site b <.001 b <.001 b <.001 b <.001
  1. SPC, second primary cancer; SIR, standardized incidence ratio; EAR, excess absolute risk; CI, confidence interval; ref, reference category.
  2. aExcluding SPC occurring in the same subsite as the first primary cancer.
  3. bDetailed results not shown.