Skip to main content

Table 3 Multivariate Poisson regression models of SPC risk a by gender, France 1989–2004 (N = 289,967)

From: The effect of patient characteristics on second primary cancer risk in France

  

Males

Females

(N = 160,807)

(N = 129,160)

  

Ratio of SIRs

P

Ratio of EARs

P

Ratio of SIRs

P

Ratio of EARs

P

  

(95% CI)

 

(95% CI)

 

(95% CI)

 

(95% CI)

 

Age at first cancer diagnosis

≤ 44 y

1.98 (1.78-2.20)

<.001

0.63 (0.54-0.75)

<.001

1.27 (1.15-1.41)

<.001

0.54 (0.40-0.72)

<.001

45 y-54 y

1.49 (1.41-1.59)

0.93 (0.84-1.04)

1.11 (1.03-1.20)

0.90 (0.72-1.13)

55 y-64 y

1.00 (ref)

1.00 (ref)

1.00 (ref)

1.00 (ref)

65 y-74 y

0.86 (0.82-0.89)

0.88 (0.78-1.00)

0.93 (0.87-0.99)

0.89 (0.69-1.14)

≥ 75

0.81 (0.77-0.85)

0.67 (0.53-0.84)

0.83 (0.77-0.89)

0.51 (0.32-0.81)

Year of first cancer diagnosis

1989-1994

1.00 (ref)

.271

1.00 (ref)

.037

1.00 (ref)

.003

1.00 (ref)

<.001

1995-1999

0.97 (0.93-1.01)

0.88 (0.79-0.97)

1.10 (1.04-1.17)

1.48 (1.19-1.84)

2000-2004

0.99 (0.95-1.03)

0.92 (0.82-1.04)

1.10 (1.03-1.18)

1.44 (1.10-1.89)

Follow-up

≥ 2 m- < 1 y

1.00 (0.95-1.06)

<.001

0.82 (0.71-0.95)

.037

1.05 (0.96-1.16)

.284

0.93 (0.62-1.33)

.006

≥ 1 y- < 2 y

1.00 (ref)

1.00 (ref)

1.00 (ref)

1.00 (ref)

≥ 2 y- < 4 y

0.99 (0.94-1.05)

1.02 (0.90-1.17)

1.02 (0.94-1.11)

1.03 (0.76-1.40)

≥ 4 y- < 6 y

0.96 (0.90-1.01)

0.96 (0.83-1.12)

1.00 (0.92-1.10)

1.07 (0.76-1.49)

≥ 6 y- < 8 y

0.95 (0.89-1.01)

1.01 (0.85-1.20)

1.07 (0.97-1.18)

1.41 (1.01-1.97)

≥ 8 y- < 10 y

0.90 (0.83-0.97)

0.90 (0.73-1.11)

1.00 (0.90-1.12)

1.31 (0.89-1.94)

≥ 10 y

0.82 (0.76-0.88)

0.87 (0.71-1.07)

1.10 (1.00-1.22)

1.83 (1.28-2.62)

First cancer site

b

<.001

b

<.001

b

<.001

b

<.001

  1. SPC, second primary cancer; SIR, standardized incidence ratio; EAR, excess absolute risk; CI, confidence interval; ref, reference category.
  2. aExcluding SPC occurring in the same subsite as the first primary cancer.
  3. bDetailed results not shown.