From: The effect of patient characteristics on second primary cancer risk in France
Males | Females | ||||||||
---|---|---|---|---|---|---|---|---|---|
(N = 160,807) | (N = 129,160) | ||||||||
Ratio of SIRs | P | Ratio of EARs | P | Ratio of SIRs | P | Ratio of EARs | P | ||
(95% CI) | (95% CI) | (95% CI) | (95% CI) | ||||||
Age at first cancer diagnosis | ≤ 44 y | 1.98 (1.78-2.20) | <.001 | 0.63 (0.54-0.75) | <.001 | 1.27 (1.15-1.41) | <.001 | 0.54 (0.40-0.72) | <.001 |
45 y-54 y | 1.49 (1.41-1.59) | 0.93 (0.84-1.04) | 1.11 (1.03-1.20) | 0.90 (0.72-1.13) | |||||
55 y-64 y | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||||
65 y-74 y | 0.86 (0.82-0.89) | 0.88 (0.78-1.00) | 0.93 (0.87-0.99) | 0.89 (0.69-1.14) | |||||
≥ 75 | 0.81 (0.77-0.85) | 0.67 (0.53-0.84) | 0.83 (0.77-0.89) | 0.51 (0.32-0.81) | |||||
Year of first cancer diagnosis | 1989-1994 | 1.00 (ref) | .271 | 1.00 (ref) | .037 | 1.00 (ref) | .003 | 1.00 (ref) | <.001 |
1995-1999 | 0.97 (0.93-1.01) | 0.88 (0.79-0.97) | 1.10 (1.04-1.17) | 1.48 (1.19-1.84) | |||||
2000-2004 | 0.99 (0.95-1.03) | 0.92 (0.82-1.04) | 1.10 (1.03-1.18) | 1.44 (1.10-1.89) | |||||
Follow-up | ≥ 2 m- < 1 y | 1.00 (0.95-1.06) | <.001 | 0.82 (0.71-0.95) | .037 | 1.05 (0.96-1.16) | .284 | 0.93 (0.62-1.33) | .006 |
≥ 1 y- < 2 y | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |||||
≥ 2 y- < 4 y | 0.99 (0.94-1.05) | 1.02 (0.90-1.17) | 1.02 (0.94-1.11) | 1.03 (0.76-1.40) | |||||
≥ 4 y- < 6 y | 0.96 (0.90-1.01) | 0.96 (0.83-1.12) | 1.00 (0.92-1.10) | 1.07 (0.76-1.49) | |||||
≥ 6 y- < 8 y | 0.95 (0.89-1.01) | 1.01 (0.85-1.20) | 1.07 (0.97-1.18) | 1.41 (1.01-1.97) | |||||
≥ 8 y- < 10 y | 0.90 (0.83-0.97) | 0.90 (0.73-1.11) | 1.00 (0.90-1.12) | 1.31 (0.89-1.94) | |||||
≥ 10 y | 0.82 (0.76-0.88) | 0.87 (0.71-1.07) | 1.10 (1.00-1.22) | 1.83 (1.28-2.62) | |||||
First cancer site | b | <.001 | b | <.001 | b | <.001 | b | <.001 |