Figure 4
From: Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib
Effect of Sorafenib and Sunitinib on VEGFR phosphorylation. Western blot analysis showing basal VEGFR2 and phosphorylated p-VEGFR2(Tyr951) in PTEC and HUVEC after 10’ or 30’ treatment with 1 μM Sunitinib (A) and 1 μM Sorafenib (B). The relative expression of p-VEGFR2(Tyr951) was normalized to basal VEGFR2. Values are expressed as mean ± S.E.M. relative to the control of three independent experiments performed with three (PTEC1, 2 and 3) and two (HUVEC) different cell lines. Statistical significance *p < 0.05.