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Table 1 Clinical correlation of Fibulin-5 expression in HCC

From: Fibulin-5 inhibits hepatocellular carcinoma cell migration and invasion by down-regulating matrix metalloproteinase-7 expression

Clinicopathologic features Total No. of patients, n = 86 No. of patients P
    Fibulin-5low Fibulin-5high  
Age (y) <50 27 15 12 0.208
≥50 59 41 18
Sex Male 69 44 25 0.597
Female 17 12 5
HBV Absent 30 19 11 0.800
Present 56 37 19
Serum AFP level (ng/mL) <400 34 24 10 0.389
≥400 52 32 20
Tumor size (cm) <5 30 22 8 0.242
≥5 56 34 22
No. of tumor nodules 1 66 49 17 0.001*
≥2 20 7 13
Cirrhosis Absent 37 26 11 0.384
Present 49 30 19
Venous infiltration Absent 42 33 9 0.011*
Present 44 23 21
Edmondson-Steiner grading I + II 29 24 5 0.014*
III + IV 57 32 25
TNM tumor stage I + II 61 44 17 0.033*
  III + IV 25 12 13  
  1. HCC, hepatocellular carcinoma; HBV, hepatitis B virus; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis. *Statistically significant.