Table 3 Distant intra-cerebral control (univariate analysis)
At 6 months | At 12 months | P-value | |
|---|---|---|---|
Treatment approach | |||
Radiosurgery alone (n = 98) | 68 | 48 | |
Radiosurgery + WBI (n = 50) | 96 | 83 | < 0.001 |
Radiosurgery dose | |||
<20 Gy (n = 63) | 72 | 63 | |
≥20 Gy (n = 85) | 82 | 59 | 0.92 |
Age | |||
≤59 years (n = 76) | 79 | 61 | |
≥60 years (n = 72) | 75 | 61 | 0.88 |
Gender | |||
Female (n = 68) | 80 | 57 | |
Male (n = 80) | 75 | 64 | 0.52 |
ECOG Performance Score | |||
0-1 (n = 93) | 77 | 61 | |
2 (n = 55) | 79 | 61 | 0.84 |
Histology | |||
Adenocarcinoma (n = 92) | 76 | 56 | |
Others (n = 56) | 81 | 71 | 0.17 |
Number of cerebral metastases | |||
1 (n = 90) | 81 | 72 | |
2-3 (n = 58) | 73 | 44 | 0.002 |
Maximum diameter of all cerebral metastases | |||
≤18 mm (n = 75) | 82 | 63 | |
≥19 mm (n = 73) | 72 | 59 | 0.16 |
Main site of cerebral metastases | |||
Supratentorial (n = 127) | 77 | 59 | |
Infratentorial (n = 21) | 82 | 72 | 0.39 |
Extra-cerebral metastases | |||
No (n = 95) | 81 | 63 | |
Yes (n = 53) | 73 | 57 | 0.36 |
Interval from lung cancer diagnosis to irradiation | |||
≤11 months (n = 77) | 83 | 58 | |
≥12 months (n = 71) | 73 | 62 | 0.75 |