Table 2 Local control of the treated cerebral metastases (univariate analysis)
At 6 months | At 12 months | P-value | |
|---|---|---|---|
Treatment approach | |||
Radiosurgery alone (n = 98) | 90 | 80 | |
Radiosurgery + WBI (n = 50) | 98 | 86 | 0.61 |
Radiosurgery dose | |||
<20 Gy (n = 63) | 88 | 76 | |
≥20 Gy (n = 85) | 97 | 87 | 0.39 |
Age | |||
≤59 years (n = 76) | 93 | 89 | |
≥60 years (n = 72) | 93 | 73 | 0.50 |
Gender | |||
Female (n = 68) | 95 | 84 | |
Male (n = 80) | 90 | 80 | 0.70 |
ECOG Performance Score | |||
0-1 (n = 93) | 96 | 88 | |
2 (n = 55) | 86 | 70 | < 0.001 |
Histology | |||
Adenocarcinoma (n = 92) | 95 | 86 | |
Others (n = 56) | 89 | 76 | 0.16 |
Number of cerebral metastases | |||
1 (n = 90) | 93 | 81 | |
2-3 (n = 58) | 92 | 84 | 0.39 |
Maximum diameter of all cerebral metastases | |||
≤18 mm (n = 75) | 91 | 87 | |
≥19 mm (n = 73) | 95 | 74 | 0.051 |
Main site of cerebral metastases | |||
Supratentorial (n = 127) | 93 | 81 | |
Infratentorial (n = 21) | 88 | 88 | 0.20 |
Extra-cerebral metastases | |||
No (n = 95) | 94 | 84 | |
Yes (n = 53) | 90 | 79 | 0.10 |
Interval from lung cancer diagnosis to irradiation | |||
≤11 months (n = 77) | 97 | 83 | |
≥12 months (n = 71) | 89 | 80 | 0.46 |