Figure 6

Effects of PKCδ inhibitor on tumor growth and survival in a xenograft human breast cancer stem cell model. Breast cancer stem cell xenografts were established and animals were treated with vehicle or rottlerin for 15 days, as described in Methods. (A) Tumor volumes plotted over time, until tumors in all the control animals reached the maximum volume allowed by the protocol (approximately 15 days). (B) Kaplan-Meier plot of survival of vehicle control or rottlerin (PKCδi)-treated animals, with monitoring continuing after cessation of treatment at day 15.