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Figure 7 | BMC Cancer

Figure 7

From: Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice

Figure 7

Loss of CD73 on hematopoietic cells did not reduce peritumoral edema after intradermal B16-F10 application. WT mice received bone marrow graft from WT or CD73−/− mice after whole-body irradiation. B16-F10 cells (1 × 106) were injected intradermally into the flank of bone barrow grafted mice. MRI measurement of tumor and peritumoral edema was performed over 14 days post injection. (A, B) Tumor and peritumoral edema volume, respectively (n = 8). (C) Loss of CD73 on hematopoietic cells did not alter intratumoral lymphoid and myeloid immune cell subsets (n = 4). (D) IFN-γ-ELISpot was performed in single cell suspensions of digested tumors containing both tumor and infiltrating immune cells. No difference was observed in the number of IFN-γ secreting cells in both groups (n = 4). Data are shown as mean ± SEM.

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