Figure 6

B16-F10 peritumoral edema but not tumor volume was reduced in CD73 ^−/− mice after intradermal injection. B16-F10 cells (1 × 10⁶) were injected intradermally into the flank of WT and CD73^−/− mice. MRI measurement of tumor and peritumoral edema was performed for 10 days post injection. Representative MR images of one WT (A) and one CD73^−/− (B) mouse bearing tumor (arrow) are shown. (C, D) Tumor volume was not altered by lack of CD73 in mice, while peritumoral edema was significantly decreased in CD73^−/− mice (n = 8 – 10). (E) No differences were observed in immune cell subsets analyzed in tumors from WT and CD73^−/− mice (n = 4 – 6). Data are shown as mean ± SEM. *p < 0.05.