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Table 2 Administered dose calculator used in the SIRFLOX study

From: Selective Internal Radiation Therapy (SIRT) with yttrium-90 resin microspheres plus standard systemic chemotherapy regimen of FOLFOX versus FOLFOX alone as first-line treatment of non-resectable liver metastases from colorectal cancer: the SIRFLOX study

  Percentage tumour involvement
BSA 0-5 6-10 11-15 16-20 21-25 26-30 31-35 36-40 41-45 46-50 51-55 56-60 61-65 66-70 71-75 76-80
  0-10% lung breakthrough
1.30-1.35 0.7 0.8 1.0 1.2 1.3 1.4 1.5 1.5 1.5 1.5 1.4 1.3 1.3 1.2 1.1 1.1
1.36-1.40 0.7 0.9 1.0 1.2 1.3 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.3 1.2 1.2 1.1
1.41-1.45 0.7 0.9 1.1 1.2 1.4 1.5 1.6 1.6 1.6 1.6 1.5 1.4 1.4 1.3 1.2 1.2
1.46-1.50 0.8 0.9 1.1 1.3 1.4 1.5 1.6 1.7 1.7 1.6 1.6 1.5 1.4 1.3 1.3 1.2
1.51-1.55 0.8 1.0 1.1 1.3 1.5 1.6 1.7 1.7 1.7 1.7 1.6 1.5 1.5 1.4 1.3 1.2
1.56-1.60 0.8 1.0 1.2 1.4 1.5 1.6 1.7 1.8 1.8 1.7 1.7 1.6 1.5 1.4 1.3 1.3
1.61-1.65 0.8 1.0 1.2 1.4 1.6 1.7 1.8 1.8 1.8 1.8 1.7 1.6 1.6 1.5 1.4 1.3
1.66-1.70 0.9 1.1 1.3 1.4 1.6 1.7 1.8 1.9 1.9 1.8 1.8 1.7 1.6 1.5 1.4 1.4
1.71-1.75 0.9 1.1 1.3 1.5 1.7 1.8 1.9 1.9 1.9 1.9 1.8 1.7 1.6 1.5 1.5 1.4
1.76-1.80 0.9 1.1 1.3 1.5 1.7 1.8 1.9 2.0 2.0 1.9 1.9 1.8 1.7 1.6 1.5 1.4
1.81-1.85 0.9 1.1 1.4 1.6 1.8 1.9 2.0 2.0 2.0 2.0 1.9 1.8 1.7 1.6 1.5 1.5
1.86-1.90 1.0 1.2 1.4 1.6 1.8 1.9 2.0 2.1 2.1 2.1 2.0 1.9 1.8 1.7 1.6 1.5
1.91-1.95 1.0 1.2 1.4 1.7 1.9 2.0 2.1 2.1 2.1 2.1 2.0 1.9 1.8 1.7 1.6 1.6
1.96-2.00 1.0 1.2 1.5 1.7 1.9 2.1 2.2 2.2 2.2 2.2 2.1 2.0 1.9 1.8 1.7 1.6
2.01-2.05 1.0 1.3 1.5 1.7 1.9 2.1 2.2 2.3 2.3 2.2 2.1 2.0 1.9 1.8 1.7 1.6
2.06-2.10 1.1 1.3 1.6 1.8 2.0 2.2 2.3 2.3 2.3 2.3 2.2 2.1 2.0 1.9 1.8 1.7
2.11-2.15 1.1 1.3 1.6 1.8 2.0 2.2 2.3 2.4 2.4 2.3 2.2 2.1 2.0 1.9 1.8 1.7
2.16-2.20 1.1 1.4 1.6 1.9 2.1 2.3 2.4 2.4 2.4 2.4 2.3 2.2 2.1 1.9 1.8 1.8
2.21-2.25 1.1 1.4 1.7 1.9 2.1 2.3 2.4 2.5 2.5 2.4 2.3 2.2 2.1 2.0 1.9 1.8
2.26-2.30 1.2 1.4 1.7 2.0 2.2 2.4 2.5 2.5 2.5 2.5 2.4 2.3 2.2 2.0 1.9 1.8
2.31-2.35 1.2 1.5 1.7 2.0 2.2 2.4 2.5 2.6 2.6 2.5 2.5 2.3 2.2 2.1 2.0 1.9
2.36-2.40 1.2 1.5 1.8 2.0 2.3 2.5 2.6 2.6 2.6 2.6 2.5 2.4 2.3 2.1 2.0 1.9
2.41-2.45 1.2 1.5 1.8 2.1 2.3 2.5 2.6 2.7 2.7 2.6 2.6 2.4 2.3 2.2 2.0 1.9
2.46-2.50 1.3 1.5 1.8 2.1 2.4 2.6 2.7 2.8 2.8 2.7 2.6 2.5 2.4 2.2 2.1 2.0
  11-15% lung breakthrough
1.30-1.35 0.7 0.8 1.0 1.2 1.3 1.4 1.5 1.5 1.5 1.5 1.4 1.3 1.3 1.2 1.1 1.1
1.36-1.40 0.7 0.9 1.0 1.2 1.3 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.3 1.2 1.2 1.1
1.41-1.45 0.7 0.9 1.1 1.2 1.4 1.5 1.6 1.6 1.6 1.6 1.5 1.4 1.4 1.3 1.2 1.2
1.46-1.50 0.8 0.9 1.1 1.3 1.4 1.5 1.6 1.7 1.7 1.6 1.6 1.5 1.4 1.3 1.3 1.2
1.51-1.55 0.8 1.0 1.1 1.3 1.5 1.6 1.7 1.7 1.7 1.7 1.6 1.5 1.5 1.4 1.3 1.2
1.56-1.60 0.8 1.0 1.2 1.4 1.5 1.6 1.7 1.8 1.8 1.7 1.7 1.6 1.5 1.4 1.3 1.3
1.61-1.65 0.8 1.0 1.2 1.4 1.6 1.7 1.8 1.8 1.8 1.8 1.7 1.6 1.6 1.5 1.4 1.3
1.66-1.70 0.9 1.1 1.3 1.4 1.6 1.7 1.8 1.9 1.9 1.8 1.8 1.7 1.6 1.5 1.4 1.4
1.71-1.75 0.9 1.1 1.3 1.5 1.7 1.8 1.9 1.9 1.9 1.9 1.8 1.7 1.6 1.5 1.5 1.4
1.76-1.80 0.9 1.1 1.3 1.5 1.7 1.8 1.9 2.0 2.0 1.9 1.9 1.8 1.7 1.6 1.5 1.4
1.81-1.85 0.9 1.1 1.4 1.6 1.8 1.9 2.0 2.0 2.0 2.0 1.9 1.8 1.7 1.6 1.5 1.5
1.86-1.90 1.0 1.2 1.4 1.6 1.8 1.9 2.0 2.0 2.0 2.0 2.0 1.9 1.8 1.7 1.6 1.5
1.91-1.95 1.0 1.2 1.4 1.7 1.9 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.8 1.7 1.6 1.6
1.96-2.00 1.0 1.2 1.5 1.7 1.9 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.8 1.7 1.6
2.01-2.05 1.0 1.3 1.5 1.7 1.9 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.8 1.7 1.6
2.06-2.10 1.1 1.3 1.6 1.8 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.8 1.7
2.11-2.15 1.1 1.3 1.6 1.8 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.8 1.7
2.16-2.20 1.1 1.4 1.6 1.9 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.8 1.8
2.21-2.25 1.1 1.4 1.7 1.9 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.8
2.26-2.30 1.2 1.4 1.7 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.8
2.31-2.35 1.2 1.5 1.7 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9
2.36-2.40 1.2 1.5 1.8 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9
2.41-2.45 1.2 1.5 1.8 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9
2.46-2.50 1.3 1.5 1.8 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0
  16-20% lung breakthrough
1.30-1.35 0.7 0.8 1.0 1.2 1.3 1.4 1.5 1.5 1.5 1.5 1.4 1.3 1.3 1.2 1.1 1.1
1.36-1.40 0.7 0.9 1.0 1.2 1.3 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.3 1.2 1.2 1.1
1.41-1.45 0.7 0.9 1.1 1.2 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.3 1.2 1.2
1.46-1.50 0.8 0.9 1.1 1.3 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.3 1.3 1.2
1.51-1.55 0.8 1.0 1.1 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.3 1.2
1.56-1.60 0.8 1.0 1.2 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.3 1.3
1.61-1.65 0.8 1.0 1.2 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.3
1.66-1.70 0.9 1.1 1.3 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4
1.71-1.75 0.9 1.1 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4
1.76-1.80 0.9 1.1 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4
1.81-1.85 0.9 1.1 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
1.86-1.90 1.0 1.2 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
1.91-1.95 1.0 1.2 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
1.96-2.00 1.0 1.2 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
2.01-2.05 1.0 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
2.06-2.10 1.1 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
2.11-2.15 1.1 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
2.16-2.20 1.1 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
2.21-2.25 1.1 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
2.26-2.30 1.2 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
2.31-2.35 1.2 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
2.36-2.40 1.2 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
2.41-2.45 1.2 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
2.46-2.50 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
  1. Dose values are given in GBq.
  2. BSA = Body surface area.