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Table 2 Administered dose calculator used in the SIRFLOX study

From: Selective Internal Radiation Therapy (SIRT) with yttrium-90 resin microspheres plus standard systemic chemotherapy regimen of FOLFOX versus FOLFOX alone as first-line treatment of non-resectable liver metastases from colorectal cancer: the SIRFLOX study

 

Percentage tumour involvement

BSA

0-5

6-10

11-15

16-20

21-25

26-30

31-35

36-40

41-45

46-50

51-55

56-60

61-65

66-70

71-75

76-80

 

0-10% lung breakthrough

1.30-1.35

0.7

0.8

1.0

1.2

1.3

1.4

1.5

1.5

1.5

1.5

1.4

1.3

1.3

1.2

1.1

1.1

1.36-1.40

0.7

0.9

1.0

1.2

1.3

1.4

1.5

1.5

1.5

1.5

1.5

1.4

1.3

1.2

1.2

1.1

1.41-1.45

0.7

0.9

1.1

1.2

1.4

1.5

1.6

1.6

1.6

1.6

1.5

1.4

1.4

1.3

1.2

1.2

1.46-1.50

0.8

0.9

1.1

1.3

1.4

1.5

1.6

1.7

1.7

1.6

1.6

1.5

1.4

1.3

1.3

1.2

1.51-1.55

0.8

1.0

1.1

1.3

1.5

1.6

1.7

1.7

1.7

1.7

1.6

1.5

1.5

1.4

1.3

1.2

1.56-1.60

0.8

1.0

1.2

1.4

1.5

1.6

1.7

1.8

1.8

1.7

1.7

1.6

1.5

1.4

1.3

1.3

1.61-1.65

0.8

1.0

1.2

1.4

1.6

1.7

1.8

1.8

1.8

1.8

1.7

1.6

1.6

1.5

1.4

1.3

1.66-1.70

0.9

1.1

1.3

1.4

1.6

1.7

1.8

1.9

1.9

1.8

1.8

1.7

1.6

1.5

1.4

1.4

1.71-1.75

0.9

1.1

1.3

1.5

1.7

1.8

1.9

1.9

1.9

1.9

1.8

1.7

1.6

1.5

1.5

1.4

1.76-1.80

0.9

1.1

1.3

1.5

1.7

1.8

1.9

2.0

2.0

1.9

1.9

1.8

1.7

1.6

1.5

1.4

1.81-1.85

0.9

1.1

1.4

1.6

1.8

1.9

2.0

2.0

2.0

2.0

1.9

1.8

1.7

1.6

1.5

1.5

1.86-1.90

1.0

1.2

1.4

1.6

1.8

1.9

2.0

2.1

2.1

2.1

2.0

1.9

1.8

1.7

1.6

1.5

1.91-1.95

1.0

1.2

1.4

1.7

1.9

2.0

2.1

2.1

2.1

2.1

2.0

1.9

1.8

1.7

1.6

1.6

1.96-2.00

1.0

1.2

1.5

1.7

1.9

2.1

2.2

2.2

2.2

2.2

2.1

2.0

1.9

1.8

1.7

1.6

2.01-2.05

1.0

1.3

1.5

1.7

1.9

2.1

2.2

2.3

2.3

2.2

2.1

2.0

1.9

1.8

1.7

1.6

2.06-2.10

1.1

1.3

1.6

1.8

2.0

2.2

2.3

2.3

2.3

2.3

2.2

2.1

2.0

1.9

1.8

1.7

2.11-2.15

1.1

1.3

1.6

1.8

2.0

2.2

2.3

2.4

2.4

2.3

2.2

2.1

2.0

1.9

1.8

1.7

2.16-2.20

1.1

1.4

1.6

1.9

2.1

2.3

2.4

2.4

2.4

2.4

2.3

2.2

2.1

1.9

1.8

1.8

2.21-2.25

1.1

1.4

1.7

1.9

2.1

2.3

2.4

2.5

2.5

2.4

2.3

2.2

2.1

2.0

1.9

1.8

2.26-2.30

1.2

1.4

1.7

2.0

2.2

2.4

2.5

2.5

2.5

2.5

2.4

2.3

2.2

2.0

1.9

1.8

2.31-2.35

1.2

1.5

1.7

2.0

2.2

2.4

2.5

2.6

2.6

2.5

2.5

2.3

2.2

2.1

2.0

1.9

2.36-2.40

1.2

1.5

1.8

2.0

2.3

2.5

2.6

2.6

2.6

2.6

2.5

2.4

2.3

2.1

2.0

1.9

2.41-2.45

1.2

1.5

1.8

2.1

2.3

2.5

2.6

2.7

2.7

2.6

2.6

2.4

2.3

2.2

2.0

1.9

2.46-2.50

1.3

1.5

1.8

2.1

2.4

2.6

2.7

2.8

2.8

2.7

2.6

2.5

2.4

2.2

2.1

2.0

 

11-15% lung breakthrough

1.30-1.35

0.7

0.8

1.0

1.2

1.3

1.4

1.5

1.5

1.5

1.5

1.4

1.3

1.3

1.2

1.1

1.1

1.36-1.40

0.7

0.9

1.0

1.2

1.3

1.4

1.5

1.5

1.5

1.5

1.5

1.4

1.3

1.2

1.2

1.1

1.41-1.45

0.7

0.9

1.1

1.2

1.4

1.5

1.6

1.6

1.6

1.6

1.5

1.4

1.4

1.3

1.2

1.2

1.46-1.50

0.8

0.9

1.1

1.3

1.4

1.5

1.6

1.7

1.7

1.6

1.6

1.5

1.4

1.3

1.3

1.2

1.51-1.55

0.8

1.0

1.1

1.3

1.5

1.6

1.7

1.7

1.7

1.7

1.6

1.5

1.5

1.4

1.3

1.2

1.56-1.60

0.8

1.0

1.2

1.4

1.5

1.6

1.7

1.8

1.8

1.7

1.7

1.6

1.5

1.4

1.3

1.3

1.61-1.65

0.8

1.0

1.2

1.4

1.6

1.7

1.8

1.8

1.8

1.8

1.7

1.6

1.6

1.5

1.4

1.3

1.66-1.70

0.9

1.1

1.3

1.4

1.6

1.7

1.8

1.9

1.9

1.8

1.8

1.7

1.6

1.5

1.4

1.4

1.71-1.75

0.9

1.1

1.3

1.5

1.7

1.8

1.9

1.9

1.9

1.9

1.8

1.7

1.6

1.5

1.5

1.4

1.76-1.80

0.9

1.1

1.3

1.5

1.7

1.8

1.9

2.0

2.0

1.9

1.9

1.8

1.7

1.6

1.5

1.4

1.81-1.85

0.9

1.1

1.4

1.6

1.8

1.9

2.0

2.0

2.0

2.0

1.9

1.8

1.7

1.6

1.5

1.5

1.86-1.90

1.0

1.2

1.4

1.6

1.8

1.9

2.0

2.0

2.0

2.0

2.0

1.9

1.8

1.7

1.6

1.5

1.91-1.95

1.0

1.2

1.4

1.7

1.9

2.0

2.0

2.0

2.0

2.0

2.0

1.9

1.8

1.7

1.6

1.6

1.96-2.00

1.0

1.2

1.5

1.7

1.9

2.0

2.0

2.0

2.0

2.0

2.0

2.0

1.9

1.8

1.7

1.6

2.01-2.05

1.0

1.3

1.5

1.7

1.9

2.0

2.0

2.0

2.0

2.0

2.0

2.0

1.9

1.8

1.7

1.6

2.06-2.10

1.1

1.3

1.6

1.8

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

1.9

1.8

1.7

2.11-2.15

1.1

1.3

1.6

1.8

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

1.9

1.8

1.7

2.16-2.20

1.1

1.4

1.6

1.9

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

1.9

1.8

1.8

2.21-2.25

1.1

1.4

1.7

1.9

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

1.9

1.8

2.26-2.30

1.2

1.4

1.7

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

1.9

1.8

2.31-2.35

1.2

1.5

1.7

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

1.9

2.36-2.40

1.2

1.5

1.8

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

1.9

2.41-2.45

1.2

1.5

1.8

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

1.9

2.46-2.50

1.3

1.5

1.8

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

2.0

 

16-20% lung breakthrough

1.30-1.35

0.7

0.8

1.0

1.2

1.3

1.4

1.5

1.5

1.5

1.5

1.4

1.3

1.3

1.2

1.1

1.1

1.36-1.40

0.7

0.9

1.0

1.2

1.3

1.4

1.5

1.5

1.5

1.5

1.5

1.4

1.3

1.2

1.2

1.1

1.41-1.45

0.7

0.9

1.1

1.2

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.4

1.4

1.3

1.2

1.2

1.46-1.50

0.8

0.9

1.1

1.3

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.4

1.3

1.3

1.2

1.51-1.55

0.8

1.0

1.1

1.3

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.4

1.3

1.2

1.56-1.60

0.8

1.0

1.2

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.4

1.3

1.3

1.61-1.65

0.8

1.0

1.2

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.4

1.3

1.66-1.70

0.9

1.1

1.3

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.4

1.4

1.71-1.75

0.9

1.1

1.3

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.4

1.76-1.80

0.9

1.1

1.3

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.4

1.81-1.85

0.9

1.1

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.86-1.90

1.0

1.2

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.91-1.95

1.0

1.2

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.96-2.00

1.0

1.2

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

2.01-2.05

1.0

1.3

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

2.06-2.10

1.1

1.3

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

2.11-2.15

1.1

1.3

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

2.16-2.20

1.1

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

2.21-2.25

1.1

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

2.26-2.30

1.2

1.4

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

2.31-2.35

1.2

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

2.36-2.40

1.2

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

2.41-2.45

1.2

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

2.46-2.50

1.3

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

  1. Dose values are given in GBq.
  2. BSA = Body surface area.
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