Figure 3
Bean-plots representing on the y -axis, the relative expression data for the two Wnt downstream targets ( AXIN2, cMYC ) and the levels of immunohistochemical expression of β-catenin (as described previously [[11]]) and along the x -axis the progression pattern by type of tissue (high-risk normal (HRN) mucosa, hyperplastic polyps (HP)/adenomatous tissue (Ad) and primary (pT) adenocarcinoma tissues). Individual observations are shown as small horizontal lines in a one-dimensional scatter plot. The estimated density of the distributions (visible as a diamond-shaped outline) together with the average for each sample subset (solid horizontal line) and the overall average (solid horizontal line across all samples) are shown. Overall there is progressive increase in the levels of expression of these genes relative to normal tissue. Expression of AXIN2 and cMYC was investigated in 13 cases, which included: normal (n = 16), hyperplastic polyp/adenoma (n = 13) and carcinoma (n = 12) samples.