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Table 3 Results of univariate and multivariate analyses of prognostic factors for PFS and OS in patients with ENKTL

From: CD30 expression is a novel prognostic indicator in extranodal natural killer/T-cell lymphoma, nasal type

Parameter

PFS

OS

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

P-value

RR (95% CI)

P-value

P-value

RR (95% CI)

P-value

Age >60 years

0.120

  

0.049

  

Gender, male

0.563

  

0.733

  

ECOG PS ≥2

0.436

  

0.341

  

Subtype, EUNKTL

0.098

  

0.022

  

B symptoms

0.001

  

0.002

  

Mass long diameter >5 cm

0.105

  

0.174

  

Local tumor invasion

0.001

  

0.003

  

Extranodal sites ≥2

0.002

  

0.007

  

Regional lymphadenopathy

0.095

  

0.301

  

Elevated serum LDH

< 0.001

  

< 0.001

  

CD 30 positive

< 0.001

4.391 (1.940–9.941)

0.001

0.002

3.345 (1.477–7.575)

0.004

Stage III, IV

< 0.001

2.841 (1.166–6.945)

0.022

< 0.001

3.497 (1.314–9.346)

0.012

IPI score ≥2

< 0.001

  

< 0.001

  

KPI score ≥2

< 0.001

  

< 0.001

  
  1. Abbreviations: PFS progression-free survival, OS overall survival, RR relative risk, CI confidence interval, ECOG PS Eastern Cooperative Oncology Group performance status, EUNKTL extra-upper aerodigestive tract NK/T-cell lymphoma, LDH lactate dehydrogenase, IPI International Prognostic Index, KPI Korean Prognostic Index.
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BMC Cancer

ISSN: 1471-2407

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