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Figure 3 | BMC Cancer

Figure 3

From: Cholesterol-conjugated let-7amimics: antitumor efficacy on hepatocellular carcinoma in vitro and in a preclinical orthotopic xenograft model of systemic therapy

Figure 3

Organelle changes after Chol-let-7a therapy under transmission electron microscopy. HepG2 and SMMC7721 cells were transfected with Chol-let-7a or the negative control miRNA mimic (Chol-miRCtrl). Cells were collected at 48 h and 60 h and observed under TEM. The figure shows the cytoplasmic ultrastructure of Chol-let-7a-treated cells at 48 h post-transfection. Also shown are heterolysosomes as phagophores (white arrows), multivesicular bodies (MVBs, yellow arrows), and multilamellar bodies (MLBs, orange arrows). Mitophagosomes (double-membrane-enclosed damaged mitochondria) and enlarged irregular mitochondria (mt) are shown with blue arrows. Red arrows indicate the dilated RER with degranulation. Scale bars are 0.5 μm or 0.2 μm.

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