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Table 4 Univariate, backwards elimination and multiple cox PH model of proteins assessed by IHC

From: Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer

PFS    
Variable Univariable Backwards elimination Multiple Cox PH model
  HRa 95% CI p-value HRa 95% CI p-value HRa 95% CI p-value
APOE epithelium 0.90 0.82-1.0 0.011 0.82 0.74-0.90 0.0007 0.82 0.74-0.90 0.0007
APOE stroma 1.34 1.10-1.63 0.002 1.48 1.22-1.79 0.0001 1.48 1.22-1.79 0.0001
AGT epithelium 0.90 0.82-1.0 0.006 0.90 0.82-1.0 0.006    
AGT stroma 0.90 0.82-1.10 0.579       
DBP epithelium 1.00 0.90-1.10 0.753       
DBP stroma 1.10 0.90-1.34 0.201       
OS          
APOE epithelium 0.90 0.82-1.0 0.179 0.90 0.82-1.0 0.043 0.90 0.82-1.0 0.04
APOE stroma 1.22 1.0-1.48 0.036 1.22 1.10-1.48 0.012 1.22 1.10-1.48 0.01
AGT epithelium 0.90 0.82-1.0 0.90       
AGT stroma 1 0.90-1.22 0.67       
DBP epithelium 1.0 0.90-1.10 0.58       
DBP stroma 1.22 1.0-1.34 0.037 1.22 1.0-1.34 0.037    
  1. aHazard ratio were calculated based on a ten percent change in protein expression.
  2. Abbreviations: AGT angiotensinogen, APOE apolipoprotein E, DBP vitamin D binding protein.