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Table 7 VEGF mRNA expression (mean ± SE) between tumor and tumor-adjacent tissues according to VEGF 3′-UTR genotypes and haplotypes

From: Interplay between 3′-UTR polymorphisms in the vascular endothelial growth factor (VEGF) gene and metabolic syndrome in determining the risk of colorectal cancer in Koreans

 

Tumor-adjacent (n = 47)

Tumor (n = 47)

p

VEGF 1451CC (n = 32)

1.00 ± 0.45

75.37 ± 35.42

0.029

VEGF 1451CT+TT (n = 15)

1.00 ± 0.84

0.59 ± 0.30

0.125

VEGF 1612GG (n = 33)

1.00 ± 0.54

52.24 ± 35.00

0.001

VEGF 1612GA+AA (n = 14)

1.00 ± 0.63

28.36 ± 18.39

0.143

VEGF 1725GG (n = 41)

1.00 ± 0.40

30.65 ± 17.78

0.011

VEGF 1725GA+AA (n = 6)

1.00 ± 0.72

39.00 ± 27.83

0.203

VEGF 1451C/1612G/1725G (n = 61)

1.00 ± 0.35

67.56 ± 26.35

<.001

VEGF 1451T/1612G/1725G (n = 18)

1.00 ± 0.81

0.50 ± 0.25

0.133

VEGF 1451C/1612A/1725G (n = 9)

1.00 ± 0.56

10.93 ± 10.43

0.481

VEGF 1451C/1612A/1725A (n = 5)

1.00 ± 0.77

39.15 ± 27.98

0.210

  1. Standard error (SE), Vascular endothelial growth factor (VEGF). p values were calculated by Wilcoxon signed rank test.