Table 2 Genotype and haplotype frequencies of VEGF 3′-UTR polymorphisms
Without MetS | With MetS | |||||
|---|---|---|---|---|---|---|
Genotype/Haplotype | Control (n = 305) | CC (n = 166) | RC (n = 113) | Control (n = 95) | CC (n = 98) | RC (n = 73) |
VEGF 1451CC | 209 (68.5) | 108 (65.1) | 64 (56.6) | 65 (68.4) | 72 (73.5) | 45 (61.6) |
VEGF 1451CT | 81 (26.6) | 50 (30.1) | 43 (38.1) | 29 (30.5) | 23 (23.5) | 27 (37.0) |
VEGF 1451TT | 15 (4.9) | 8 (4.8) | 6 (5.3) | 1 (1.1) | 3 (3.1) | 1 (1.4) |
HWE-p | 0.059 | 0.483 | 0.724 | 0.251 | 0.493 | 0.167 |
VEGF 1612GG | 213 (69.8) | 127 (76.5) | 87 (77.0) | 67 (70.5) | 68 (69.4) | 54 (74.0) |
VEGF 1612GA | 83 (27.2) | 36 (21.7) | 21 (18.6) | 27 (28.4) | 29 (29.6) | 18 (24.7) |
VEGF 1612AA | 9 (3.0) | 3 (1.8) | 5 (4.4) | 1 (1.1) | 1 (1.0) | 1 (1.4) |
HWE-p | 0.791 | 0.809 | 0.022 | 0.336 | 0.271 | 0.714 |
VEGF 1725GG | 278 (91.1) | 147 (88.6) | 96 (85.0) | 81 (85.3) | 79 (80.6) | 61 (83.6) |
VEGF 1725GA | 27 (8.9) | 19 (11.4) | 17 (15.0) | 14 (14.7) | 19 (19.4) | 12 (16.4) |
VEGF 1725AA | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
HWE-p | 0.419 | 0.434 | 0.387 | 0.438 | 0.288 | 0.444 |
VEGF 1451C/1612G/1725G | 398 (65.2) | 221 (65.6) | 140 (61.9) | 130 (68.4) | 134 (68.4) | 96 (65.8) |
VEGF 1451T/1612G/1725G | 111 (18.2) | 66 (19.9) | 55 (24.3) | 31 (16.3) | 29 (14.8) | 29 (19.9) |
VEGF 1451C/1612A/1725G | 74 (12.1) | 26 (7.8) | 14 (6.2) | 15 (7.9) | 14 (7.1) | 9 (6.2) |
VEGF 1451C/1612A/1725A | 27 (4.4) | 16 (4.8) | 17 (7.5) | 14 (7.4) | 17 (8.7) | 11 (7.5) |
VEGF 1451C/1612G/1725A | 0 (0.0) | 3 (0.9) | 0 (0.0) | 0 (0.0) | 2 (1.0) | 1 (0.7) |