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Table 2 T 1 sensitivity and specificity tables for changes in RIF-1 tumour volume following everolimus or patupilone treatment

From: Tumour T1 changes in vivo are highly predictive of response to chemotherapy and reflect the number of viable tumour cells – a preclinical MR study in mice

A. Everolimus: using a ΔT1 of −8%
  ΔTVol  
ΔT1 Positive Negative Total
Positive 5 3 8
Negative 0 5 5
Total 5 8 13
B. Patupilone: using a ΔT1 of −8%.
  ΔTVol  
ΔT 1 Positive Negative Total
Positive 7 3 10
Negative 0 10 10
Total 7 13 20
  1. A. Everolimus: The prevalence (total positive/all) = 0.38. The sensitivity =1.0 and the 1- specificity = 0.38, giving a positive prediction value of 0.63 and a negative prediction value of 1.0 at this ΔT1 cut-off of −8%.
  2. B. Patupilone: The prevalence (total positive/all) = 0.35. The sensitivity =1.0 and the 1- specificity = 0.23, giving a positive prediction value of 0.70 and a negative prediction value of 1.0 at this ΔT1 cut-off of −8%.