Figure 1

Everolimus decreases the T ₁ of RIF-1 tumours. C3H mice bearing RIF-1 tumours were treated with everolimus (10 mg/kg/day) or vehicle for 5 days and the spin–lattice relaxation of protons (T₁) in tumours was measured on day 0 and at the endpoint day 5. Results show the individual values for each tumour, n = 7 per treatment group (A) and the mean ± SEM fractional change ΔT₁ for each treatment (B), where *p < 0.05, **p < 0.01, ***p < 0.001 as shown. Panel C &D show an MRI-derived T₁ map from a representative RIF-1 tumour (arrow) before (C) and after (D) treatment with everolimus.