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Table 2 Quantitative analyses of PET findings using three tracers in patients with HNSCC

From: Hypoxia, blood flow and metabolism in squamous-cell carcinoma of the head and neck: correlations between multiple immunohistochemical parameters and PET

 

[18F]FDG

[18F]FETNIM

[15O]H2O

Patient no.

SUVa

Tumor volumeb(cm3)

FHVc(%)

T/P ratiod

Blood flow (ml/100 mg/min)

1

18.5

8.3

9.5

0.91

35.3

2

14.9

3.4

10.5

0.72

29.7

3

19.0

34.1

61.6

1.41

44.4

4

8.4

9.9

61.4

1.98

63.1

5

17.3

401.6

39.2

1.49

44.8

6

11.7

53.6

54.2

1.24

23.7

7

7.6

1.7

17.8

0.95

12.4

8

18.3

141.1

55.7

1.34

29.6

9

13.0

22.2

48.0

1.07

n.d.

10

7.8

5.5

50.5

1.11

26.2

11

28.8

23.6

19.7

1.00

19.7

12

9.6

12.6

34.0

1.02

37.9

13

7.2

5.0

10.1

0.82

24.3

14

19.6

52.6

63.2

1.37

41.0

15

5.3

1.4

62.3

1.10

31.0

Mean ± SD

13.8 ± 6.5

51.8 ± 103.2

39.8 ± 21.1

1.17 ± 0.32

33.1 ± 12.7

Median (range)

13.0 (5.3 – 28.8)

12.6 (1.4 – 401.6)

48.0 (9.5 – 63.2)

1.10 (0.72 – 1.98)

30.4 (12.4 – 63.1)

  1. astandardized uptake value.
  2. bmetabolically active volume as determined from [18F]FDG PET.
  3. cfractional hypoxic volume.
  4. dmaximum tumor-to-plasma radioactivity at 90 – 120 min.
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