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Table 4 The association between thyroid function/autoimmunity biomarkers and thyroid cancer risk, stratified by the presence of TPOAb

From: Biomarkers of thyroid function and autoimmunity for predicting high-risk groups of thyroid cancer: a nested case–control study

 

TPOAb (IU/mL)

 

<30

≥30

 

Controls/cases

Adjusted OR (95% CI)c

Controls/cases

Adjusted OR (95% CI)c

TT3 (ng/mL)

    

  <1.2

67/29

1.0(ref)

21/50

1.0(ref)

  1.2 - <1.4

74/32

1.03(0.55 - 1.91)

30/77

1.05(0.53 - 2.07)

  ≥1.4

51/16

0.71(0.34 - 1.49)

14/53

1.71(0.76 - 3.85)

FT4 (ng/dL)

    

  <1.25

66/18

1.0(ref)

19/50

1.0(ref)

  1.25 - <1.39

62/21

1.14(0.55 - 2.40)

23/54

0.87(0.42 - 1.80)

  ≥1.39

64/38

2.12(1.06 - 4.24)*

23/76

1.37(0.66 - 2.83)

TSH (μIU/mL)

    

  <1.36

66/16

1.0(ref)

18/43

1.0(ref)

  1.36 - <2.5

63/32

2.00(1.00 - 4.01)*

23/79

1.48(0.73 - 3.00)

  ≥2.5

63/28

1.82(0.89 - 3.72)

21/56

1.14(0.54 - 2.40)

Tg (ng/mL)a

    

  0 - <3.9

58/22

1.0(ref)

19/45

1.0(ref)

  3.9 - <7

59/18

0.70(0.34 - 1.44)

15/46

1.28(0.57 - 2.86)

  ≥7

63/32

1.21(0.63 - 2.32)

14/63

1.95(0.87 - 4.38)

TgAb (U/mL)b

    

  <20

170/69

1.0(ref)

42/134

1.0(ref)

  ≥20

22/8

0.95(0.40 - 2.26)

23/46

0.59(0.31 - 1.14)

  1. Abbreviations: CI, Confidence interval; OR, Odds ratio; TT3, Total triiodothyronine; FT4, Free thyroxine; TSH, Thyroid-stimulating hormone; Tg, Thyroglobulin; TgAb, Anti-thyroglobulin antibody; TPOAb, Anti-thyroperoxidase antibody.
  2. aAnalyzed only for TgAb-negative subjects; bThe detection limits used were 20 IU/mL for TgAb, and we combined these groups into two groups because of the small sample sizes; cAdjusted for age, sex, BMI, and smoking.
  3. * P <0.05.
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BMC Cancer

ISSN: 1471-2407

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