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Table 4 The association between thyroid function/autoimmunity biomarkers and thyroid cancer risk, stratified by the presence of TPOAb

From: Biomarkers of thyroid function and autoimmunity for predicting high-risk groups of thyroid cancer: a nested case–control study

  TPOAb (IU/mL)
  <30 ≥30
  Controls/cases Adjusted OR (95% CI)c Controls/cases Adjusted OR (95% CI)c
TT3 (ng/mL)     
  <1.2 67/29 1.0(ref) 21/50 1.0(ref)
  1.2 - <1.4 74/32 1.03(0.55 - 1.91) 30/77 1.05(0.53 - 2.07)
  ≥1.4 51/16 0.71(0.34 - 1.49) 14/53 1.71(0.76 - 3.85)
FT4 (ng/dL)     
  <1.25 66/18 1.0(ref) 19/50 1.0(ref)
  1.25 - <1.39 62/21 1.14(0.55 - 2.40) 23/54 0.87(0.42 - 1.80)
  ≥1.39 64/38 2.12(1.06 - 4.24)* 23/76 1.37(0.66 - 2.83)
TSH (μIU/mL)     
  <1.36 66/16 1.0(ref) 18/43 1.0(ref)
  1.36 - <2.5 63/32 2.00(1.00 - 4.01)* 23/79 1.48(0.73 - 3.00)
  ≥2.5 63/28 1.82(0.89 - 3.72) 21/56 1.14(0.54 - 2.40)
Tg (ng/mL)a     
  0 - <3.9 58/22 1.0(ref) 19/45 1.0(ref)
  3.9 - <7 59/18 0.70(0.34 - 1.44) 15/46 1.28(0.57 - 2.86)
  ≥7 63/32 1.21(0.63 - 2.32) 14/63 1.95(0.87 - 4.38)
TgAb (U/mL)b     
  <20 170/69 1.0(ref) 42/134 1.0(ref)
  ≥20 22/8 0.95(0.40 - 2.26) 23/46 0.59(0.31 - 1.14)
  1. Abbreviations: CI, Confidence interval; OR, Odds ratio; TT3, Total triiodothyronine; FT4, Free thyroxine; TSH, Thyroid-stimulating hormone; Tg, Thyroglobulin; TgAb, Anti-thyroglobulin antibody; TPOAb, Anti-thyroperoxidase antibody.
  2. aAnalyzed only for TgAb-negative subjects; bThe detection limits used were 20 IU/mL for TgAb, and we combined these groups into two groups because of the small sample sizes; cAdjusted for age, sex, BMI, and smoking.
  3. * P <0.05.