Sex | BMI (kg/m2) | Smoking | Follow-up duration | |||||
---|---|---|---|---|---|---|---|---|
Men | Women | <23 | ≥23 | Non-smoker | Former/Current smoker | < 3 years | ≥3 years | |
Controls/Cases | 77/77 | 180/180 | 125/95 | 132/162 | 147/158 | 80/70 | 97/171 | 160/86 |
TT3 (ng/mL) | ||||||||
<1.2 | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) |
1.2 - <1.4 | 1.66(0.68 - 4.04) | 1.08(0.67 - 1.75) | 1.16(0.63 - 2.15) | 1.18(0.67 - 2.08) | 0.92(0.55 - 1.54) | 2.07(0.85 - 5.02) | 1.81(1.03 - 3.20)* | 0.93(0.47 - 1.83) |
≥1.4 | 1.56(0.61 - 4.00) | 1.22(0.69 - 2.14) | 0.93(0.43 - 2.00) | 1.50(0.81 - 2.78) | 0.80(0.43 - 1.51) | 1.97(0.80 - 4.89) | 2.51(1.21 - 5.22)* | 1.10(0.53 - 2.25) |
FT4 (ng/dL) | ||||||||
<1.25 | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) |
1.25 - <1.39 | 0.65(0.23 - 1.80) | 1.19(0.71 - 2.00) | 1.37(0.62 - 2.89) | 0.91(0.51 - 1.64) | 0.82(0.46 - 1.46) | 1.05(0.42 - 2.66) | 1.58(0.84 - 2.97) | 0.73(0.36 - 1.46) |
≥1.39 | 1.44(0.53 - 3.88) | 1.76(1.06 - 2.92)* | 2.52(1.28 - 4.96)* | 1.43(0.78 - 2.60) | 1.46(0.83 - 2.56) | 1.85(0.77 - 4.41) | 3.01(1.57 - 5.77)* | 1.10(0.57 - 2.10) |
TSH (μIU/mL) | ||||||||
<1.36 | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) |
1.36 - <2.5 | 2.31(1.06 - 5.02)* | 1.58(0.92 - 2.72) | 1.16(0.59 - 2.29) | 2.31(1.30 - 4.13)* | 1.71(0.95 - 3.09) | 2.44(1.14 - 5.24)* | 2.07(1.11 - 3.88)* | 1.57(0.80 - 3.06) |
≥2.5 | 1.97(0.76 - 5.08) | 1.16(0.68 - 1.97) | 0.96(0.49 - 1.89) | 1.82(0.98 - 3.37) | 1.23(0.68 - 2.22) | 1.33(0.53 - 3.38) | 1.36(0.72 - 2.59) | 1.41(0.70 - 2.83) |
Tg (ng/mL)b | ||||||||
0 - <3.9 | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) |
3.9 - <7 | 1.09(0.46 - 2.57) | 0.93(0.52 - 1.66) | 1.09(0.52 - 2.30) | 0.95(0.52 - 1.77) | 0.77(0.41 - 1.43) | 1.16(0.48 - 2.79) | 1.75(0.87 - 3.52) | 0.65(0.32 - 1.33) |
≥7 | 2.98(1.23 - 7.17)* | 1.08(0.63 - 1.83) | 1.09(0.55 - 2.14) | 1.89(1.02 - 3.49)* | 0.98(0.55 - 1.75) | 2.52(1.05 - 6.03)* | 1.80(0.96 - 3.36) | 1.06(0.54 - 2.10) |
TgAb (IU/mL)c | ||||||||
<20 | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) |
20 - <60 | 1.77(0.31 - 10.20) | 1.56(0.77 - 3.19) | 1.92(0.77 - 4.79) | 1.27(0.50 - 3.26) | 1.54(0.71 - 3.33) | 1.33(0.28 - 6.26) | 1.25(0.55 - 2.83) | 1.17(0.35 - 3.89) |
≥60 | 0.25(0.03 - 2.22) | 1.31(0.71 - 2.41) | 1.16(0.49 - 2.77) | 1.11(0.52 - 2.37) | 1.14(0.53 - 2.47) | 1.07(0.30 - 3.79) | 1.67(0.71 - 3.92) | 0.77(0.32 - 1.87) |
TPOAb (IU/mL)c | ||||||||
<30 | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) | 1.0(ref) |
30 - <60 | 5.59(2.57 - 12.16)* | 10.67(6.03 - 18.88)* | 8.77(4.30 - 17.86)* | 8.40(4.62 - 15.24)* | 10.96(5.85 - 20.53)* | 4.97(2.31 - 10.69)* | 6.10(3.10 - 11.67)* | 14.75(2.36 - 29.56)* |
≥60 | 3.89(1.05 - 14.41)* | 4.60(2.50 - 8.46)* | 4.43(1.95 - 10.04)* | 4.41(2.10 - 9.26)* | 3.52(1.78 - 6.96)* | 6.35(1.80 - 22.41)* | 4.54(2.10 - 9.84)* | 4.32(1.77 - 10.52)* |