Figure 3

Whole genome duplication. Scatter plots of whole genome duplication (WGD) score and average ploidy indicate strong correlation between hyperploidy and evidence of genome duplication, neither of which associated with tumour dissemination or relative loss of 1p36. Absolute loss of 1p36 (which is also counted as relative loss) was almost exclusive to near-diploid genomes. The histograms show bi-modal distributions for the WGD score, which suggests two groups of samples; one having undergone WGD and the other not. A) Samples of the current study (MSS, 92) with tumour dissemination (metastatic disease) in blue. B) TCGA validation samples (MSS/CIN, 252), metastatic at diagnosis in blue and with no metastasis at diagnosis and long-term survival in black.