Figure 2

Relative loss on 1p36. A) Frequency of relative loss (<67% of individual sample average copy number) on 1p36 when comparing disseminated (metastatic SII-IV) and non-disseminated (SII-III) colon cancer, MSI excluded. High difference in frequency extended through 1p36.11-21 and included multiple cancer-related genes. B) TCGA validation set. Frequency of relative loss on 1p36, comparing stage IV cases with cases non-metastatic at diagnosis and with long-term survival. C) Total frequencies of relative loss were very similar in the current study and the TCGA validation set. Focal deletion of RHD (1p36.11) is a common germline polymorphism, likely not associated with the cancer.